https://research-information.bris.ac.uk/ws/files/259213304/PIIS0140673620309259.pdf

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

https://digital.library.adelaide.edu.au/dspace/bitstream/2440/129488/3/hdl_129488.pdf

Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

http://www.thelancet.com/article/S0140673621027240/pdf

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death worldwide. Risk factors for HCC include chronic hepatitis B and hepatitis C, alcohol addiction, metabolic liver disease (particularly nonalcoholic fatty liver disease) and exposure to dietary toxins such as aflatoxins and aristolochic acid. All these risk factors are potentially preventable, highlighting the considerable potential of risk prevention for decreasing the global burden of HCC. HCC surveillance and early detection increase the chance of potentially curative treatment; however, HCC surveillance is substantially underutilized, even in countries with sufficient medical resources. Early-stage HCC can be treated curatively by local ablation, surgical resection or liver transplantation. Treatment selection depends on tumour characteristics, the severity of underlying liver dysfunction, age, other medical comorbidities, and available medical resources and local expertise. Catheter-based locoregional treatment is used in patients with intermediate-stage cancer. Kinase and immune checkpoint inhibitors have been shown to be effective treatment options in patients with advanced-stage HCC. Together, rational deployment of prevention, attainment of global goals for viral hepatitis eradication, and improvements in HCC surveillance and therapy hold promise for achieving a substantial reduction in the worldwide HCC burden within the next few decades.

/pdf/a-global-view-of-hepatocellular-carcinoma-trends-risk-26dq6hubb1.pdf

A global view of hepatocellular carcinoma: trends, risk, prevention and management.

Prolonged second stage labour is thought to be a risk factor for obstetric and perinatal complications. However, its effect on complications has been found to be inconclusive by a broad range of studies. This study aimed to investigate the relationship between adverse maternal and neonatal outcomes and prolonged second stage of labour in northern Ethiopia. This retrospective cohort study included 1055 systematically selected records of women who gave birth between 1 September 2014 and 30 August 2017. Binary and multivariable logistic regression models were used to test the effect of prolonged second stage labour on maternal and neonatal outcomes. Adverse outcomes significantly associated with prolonged second stage labour were: operative vaginal birth (P<0.010), caesarean birth (P<0.010), puerperal sepsis (P=0.010) and third- or fourth-degree perineal tears (P=0.028), episiotomy (P=0.003), a 5-minute Apgar score <7 (P=0.030) and meconium-stained amniotic fluid (P<0.010). Multiple adverse outcomes were significantly associated with prolonged second stage labour. Therefore, close monitoring, follow up and timely interventions are needed for women experiencing prolonged second stage labour.

Prolonged second stage labour and maternal-neonatal outcomes in northern Ethiopia: a retrospective cohort study

Background: A skilled birth attendance for every pregnant woman during childbirth is the most crucial intervention for improving maternal health. This study aimed to assess institutional delivery service utilization and associated factors among mothers who gave birth in the last 12 months in Raya Kobo district, Ethiopia.
Methods: A community-based cross-sectional study was carried out in the Raya Kobo district of Amhara Regional State during March 2016. Logistic regression analysis was performed to assess the association between each independent variable and the outcome variable. Variables with a p-value <0.05 were considered significant.
Results: A total of 493 mothers were included in the study, with a response rate of 95.4%. The mean (+SD) age of the study participants was 29.13 (±6.93) years. About 73% of the study participants had attended at least one antenatal care follow up for their last pregnancy, and 56.6% (95% CI: 52.0, 61.0%) gave birth at health institutions. Travelling for 30 minutes and less [AOR=2.95(1.89, 4.58)], attending antenatal care [AOR=6.0(3.55, 10.13)], having knowledge about intrapartum danger signs [AOR=2.48(1.44, 4.24)] and getting information from health extension workers (HEWs) regarding maternal health services were positively associated.
Conclusion: The district health office should strengthen its effort to provide free ambulance accessibility and provide information on danger signs of intrapartum complications and the importance of using institutional delivery service to every mother who came to the antenatal clinic. Furthermore, the district health officials should focus on strengthening the capacity of HEWs in relation to maternal health services.

Knowledge on Intrapartum Danger Sign Influences Place of Delivery: The Case of Raya Kobo District, Northeastern Ethiopia

Breastfeeding is sufficient for infants in the first 6 months of life and is important to maintain maternal health. Evidences revealed that neonatal mortality is higher among children who received ...

https://journals.sagepub.com/doi/pdf/10.1177/2333794X211013764

Nigus Bililign Yimer

Papers

Prolonged second stage labour and maternal-neonatal outcomes in northern Ethiopia: a retrospective cohort study

Knowledge on Intrapartum Danger Sign Influences Place of Delivery: The Case of Raya Kobo District, Northeastern Ethiopia

The effect of antenatal care on colostrum avoidance in pastoralists: The case of Afar, Northeast Ethiopia.