Nikola Milašinović

TL;DR: In this paper, a pH-sensitive hydrogel based on chitosan, itaconic acid and methacrylic acid was synthesized in two steps and the results showed that the gels demonstrate substantial change in buffer absorbency with change of pH, low for acid buffers and the higher for pH values above 6 where the swelling is considerably slow.

TL;DR: Both, the increase in the amount of the crosslinking agent and the presence of polyphenols contributed to a more pronounced surface roughness of microbeads.

TL;DR: Temperature- and pH-sensitive hydrogels, based on N-isopropylacrylamide and itaconic acid, synthesized by free radical crosslinking copolymerization in the presence of lipase from Candida rugosa were found suitable for releasing therapeutic proteins in a controlled manner at specific sites in gastrointestinal tract.

TL;DR: Temperature- and pH-sensitive hydrogels based on N-isopropylacrylamide (NiPAAm) and itaconic acid (IA) were applied for immobilization of lipase from Candida rugosa and improved pH and temperature optima values were obtained.

TL;DR: In this article, a commercial Candida rugosa lipase was immobilized into poly(N-isopropylacrylamide-co-itaconic acid) hydrogel under different pH immobilization conditions, characterized and evaluated for both hydrolytic activity in an aqueous medium and esterolytic activation in an organic medium.