N
Nikolay V. Goncharov
Researcher at Russian Academy of Sciences
Publications - 74
Citations - 657
Nikolay V. Goncharov is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Albumin & Medicine. The author has an hindex of 10, co-authored 62 publications receiving 445 citations. Previous affiliations of Nikolay V. Goncharov include Federal Biomedical Agency & Saint Petersburg State University.
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Toxicology of fluoroacetate: a review, with possible directions for therapy research
TL;DR: This review deals with the clinical signs and physiological and biochemical mechanisms of FA intoxication to provide an explanation of why, even after decades of investigation, has no effective therapy to FA intoxication been elaborated.
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Serum Albumin Binding and Esterase Activity: Mechanistic Interactions with Organophosphates.
Nikolay V. Goncharov,Daria A. Belinskaia,V. I. Shmurak,Maxim A. Terpilowski,Richard O. Jenkins,Pavel V. Avdonin +5 more
TL;DR: Information is given on the substrate specificity of albumin and the possibility of its affiliation to certain classes in the nomenclature of enzymes is considered, which could help in the development of new types of antidotes.
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Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting and Signaling Properties.
TL;DR: In this paper, a review of the esterase, antioxidant, transporting and signaling properties of albumin, as well as its structural and functional modifications and their significance in the pathogenesis of certain diseases is presented.
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The Universal Soldier: Enzymatic and Non-Enzymatic Antioxidant Functions of Serum Albumin.
Daria A. Belinskaia,Polina A Voronina,V. I. Shmurak,Mikhail A. Vovk,A. A. Batalova,Richard O. Jenkins,Nikolay V. Goncharov +6 more
TL;DR: It has been concluded that it is fundamentally possible to regulate the antioxidant properties of albumin with various ligands, and the binding and/or enzymatic features of the protein by changing its redox status.
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A novel strategy for the synthesis of thermally stable and apoptosis-inducing 2,3-dihydroazetes
Ilia A. Smetanin,Mikhail S. Novikov,Anastasiya V. Agafonova,Nikolai V. Rostovskii,Alexander F. Khlebnikov,Igor Kudryavtsev,Maxim A. Terpilowski,Maria K. Serebriakova,Andrey S. Trulioff,Nikolay V. Goncharov +9 more
TL;DR: In vitro cytotoxicity tests on THP-1 cell line revealed that the 2,3-dihydroazetes greatly differ in their ability to induce apoptosis and/or necrosis, and trimethyl 4-phenyl-2,3,dihYDroazete- 2,2, 3-tricarboxylate was found to display the maximal apoptotic potential coupled with high cytotoxic and minimal necrotic potential.