Showing papers by "Nikoletta Rovina published in 2016"
TL;DR: The aim of this review is to explore the mechanical properties of the respiratory system in BD patients along with the underlying mechanisms, and to translate the evidence of animal and clinical studies into therapeutic implications regarding the mechanical ventilation of these critically ill patients.
Abstract: Several clinical and experimental studies have shown that lung injury occurs shortly after brain damage. The responsible mechanisms involve neurogenic pulmonary edema, inflammation, the harmful action of neurotransmitters, or autonomic system dysfunction. Mechanical ventilation, an essential component of life support in brain-damaged patients (BD), may be an additional traumatic factor to the already injured or susceptible to injury lungs of these patients thus worsening lung injury, in case that non lung protective ventilator settings are applied. Measurement of respiratory mechanics in BD patients, as well as assessment of their evolution during mechanical ventilation, may lead to preclinical lung injury detection early enough, allowing thus the selection of the appropriate ventilator settings to avoid ventilator-induced lung injury. The aim of this review is to explore the mechanical properties of the respiratory system in BD patients along with the underlying mechanisms, and to translate the evidence of animal and clinical studies into therapeutic implications regarding the mechanical ventilation of these critically ill patients.
29 citations
TL;DR: A "dose-response" effect of chronic exposure to a polluted environment on bronchial and systemic inflammation in professional firefighters is indicated.
24 citations
28 Jul 2016
TL;DR: Asthma-chronic obstructive pulmonary disease overlap syndrome: A diagnostic puzzle for the clinicians
Abstract: Asthma-chronic obstructive pulmonary disease overlap syndrome: A diagnostic puzzle for the clinicians
1 citations