A
Antonia Koutsoukou
Researcher at National and Kapodistrian University of Athens
Publications - 137
Citations - 4789
Antonia Koutsoukou is an academic researcher from National and Kapodistrian University of Athens. The author has contributed to research in topics: Medicine & Mechanical ventilation. The author has an hindex of 25, co-authored 114 publications receiving 3328 citations. Previous affiliations of Antonia Koutsoukou include Athens State University & University of Nebraska Medical Center.
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Journal ArticleDOI
Complex immune dysregulation in covid-19 patients with severe respiratory failure
Evangelos J. Giamarellos-Bourboulis,Mihai G. Netea,Mihai G. Netea,Nikoletta Rovina,Karolina Akinosoglou,Anastasia Antoniadou,Nikolaos Antonakos,Georgia Damoraki,Theologia Gkavogianni,Maria Evangelia Adami,Paraskevi Katsaounou,Maria Ntaganou,Magdalini Kyriakopoulou,George Dimopoulos,Ioannis Koutsodimitropoulos,Dimitrios Velissaris,Panagiotis Koufargyris,Athanassios Karageorgos,Konstantina Katrini,Vasileios Lekakis,Mihaela Lupse,Antigone Kotsaki,George Renieris,Danai Theodoulou,Vassiliki Panou,Evangelia Koukaki,Nikolaos Koulouris,Charalambos Gogos,Antonia Koutsoukou +28 more
TL;DR: In this paper, the authors found that severe respiratory failure (SRF) in COVID-19 patients is driven by a unique pattern of immune dysfunction, characterized by IL-6-mediated low HLA-DR expression and lymphopenia, associated with sustained cytokine production and hyper-inflammation.
Journal ArticleDOI
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison.
Ioanna E. Galani,Nikoletta Rovina,Vicky Lampropoulou,Vasiliki Triantafyllia,Maria Manioudaki,Eleftherios Pavlos,Evangelia Koukaki,Paraskevi C. Fragkou,Vasiliki Panou,Vasiliki Rapti,Ourania Koltsida,Andreas Mentis,Nikolaos Koulouris,Sotirios Tsiodras,Antonia Koutsoukou,Evangelos Andreakos,Evangelos Andreakos +16 more
TL;DR: A dysregulated interferon response whereby IFN-λ and type I IFN production were diminished and delayed in patients with COVID-19, exhibiting a response that is ‘untuned’ with other inflammatory cytokines is reported.
Journal ArticleDOI
Inflammation and Immune Response in COPD: Where Do We Stand?
TL;DR: In smokers who develop COPD there appears to be a specific pattern of inflammation in the airways and parenchyma as a result of both innate and adaptive immune responses, with the predominance of CD8+.
Posted ContentDOI
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison
Ioanna E. Galani,Nikoletta Rovina,Vicky Lampropoulou,Vasiliki Triantafyllia,Maria Manioudaki,Eleftherios Pavlos,Evangelia Koukaki,Paraskevi C. Fragkou,Vasiliki Panou,Vasiliki Rapti,Ourania Koltsida,Andreas Mentis,Nikolaos Koulouris,Sotirios Tsiodras,Antonia Koutsoukou,Evangelos Andreakos +15 more
TL;DR: Altered cytokine patterns in COVID-19 patients correlate with longer hospitalization time and higher incidence of critical disease and mortality compared to flu, pointing to an untuned antiviral response in CO VID-19 contributing to persistent viral presence, hyperinflammation and respiratory failure.
Journal ArticleDOI
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Anna C. Aschenbrenner,Maria Mouktaroudi,Benjamin Krämer,Marie Oestreich,Nikolaos Antonakos,Melanie Nuesch-Germano,Konstantina Gkizeli,Lorenzo Bonaguro,Nico Reusch,Kevin Baßler,Maria Saridaki,Rainer Knoll,Tal Pecht,Theodore S. Kapellos,Sarandia Doulou,Charlotte Kröger,Miriam Herbert,Lisa Holsten,Arik Horne,Ioanna D. Gemünd,Nikoletta Rovina,Shobhit Agrawal,Kilian Dahm,Martina van Uelft,Anna Drews,Lena Lenkeit,Niklas Bruse,Jelle Gerretsen,Jannik Gierlich,Matthias Becker,Kristian Händler,Michael Kraut,Heidi Theis,Simachew Mengiste,Elena De Domenico,Jonas Schulte-Schrepping,Lea Seep,Jan Raabe,Christoph Hoffmeister,Michael ToVinh,Verena Keitel,Gereon Rieke,Valentina Talevi,Dirk Skowasch,N. Ahmad Aziz,N. Ahmad Aziz,Peter Pickkers,Frank L. van de Veerdonk,Mihai G. Netea,Mihai G. Netea,Joachim L. Schultze,Joachim L. Schultze,Matthijs Kox,Monique M.B. Breteler,Monique M.B. Breteler,Jacob Nattermann,Antonia Koutsoukou,Evangelos J. Giamarellos-Bourboulis,Thomas Ulas +58 more
TL;DR: This article performed RNA-seq of whole blood cell transcriptomes and granulocyte preparations from mild and severe COVID-19 patients and analyzed the data using a combination of conventional and data-driven co-expression analysis.