Nils Schlimmer

TL;DR: Selective heart rate reduction with ivabradine decreases markers of vascular oxidative stress, improves endothelial function, and reduces atherosclerotic plaque formation in apolipoprotein E–deficient mice.

TL;DR: Erectile dysfunction is a major problem with an increasing prevalence in cardiovascular high‐risk patients due to its association with cardiovascular risk factors and drugs used for evidence‐based treatment of cardiovascular diseases are reported to decrease erectile function.

TL;DR: Treatment with irbesartan alone, as well as in combination with hydrochlorothiazide is associated with an improvement of sexual desire, frequency of sexual contacts and erectile function in hypertensive patients with the metabolic syndrome, suggesting a beneficial role of angiotensin receptor antagonists in the treatment of metabolic syndrome and ED.

TL;DR: Ivabradine improves penile endothelial function by reduction of oxidative stress and penile fibrosis and Beneficial effects were achieved in prevention and manifest endothelial dysfunction.

TL;DR: Nebivolol improves penile endothelial function as a surrogate of erectile function in ApoE-/- mice, which may be related to a reduction of ROS production, which is independent of heart rate reduction, because metoprolol did not increase endothelium function.