Nina Wale

TL;DR: A conceptual framework is provided describing the information required to effectively manage drug pressure to minimize resistance evolution and the very limited available empirical evidence across different pathogens is summarized.

TL;DR: This work shows that the emergence of drug resistance can be prevented by reducing the availability of a nutrient for which drug-resistant parasites are especially hungry, and provides proof of principle that chemotherapy paired with an “ecological” intervention can slow the evolution of resistance to antimicrobial drugs, even when resistant pathogens are present at high frequencies.

TL;DR: It is demonstrated that a parasite nutrient, para-aminobenzoic acid (pABA), mediates competition between a drug resistant and drug susceptible strain of the malaria parasite, Plasmodium chabaudi, and that increasing pABA supply to hosts infected with the resistant strain worsens disease and changes the relationship between parasite burden and pathology.

TL;DR: This introduction to the Special Feature on Model Systems in Ecology, Evolution, and Behavior (EEB), grappling with the question, What is a model system is begun, and the importance of communities of scientists in the success of model systems is emphasized—narrow scientific communities can restrict the model organisms themselves.

TL;DR: It is found that hosts control infections not only by killing pathogens, but by starving parasites and shortening the lifespans of cells on which they depend, revealing that some immune responses seen as harmful to the host may in fact be helpful and suggesting simple rules that govern the immune response’s deployment.