S
Sebastian Bonhoeffer
Researcher at ETH Zurich
Publications - 275
Citations - 27281
Sebastian Bonhoeffer is an academic researcher from ETH Zurich. The author has contributed to research in topics: Population & Virus. The author has an hindex of 77, co-authored 265 publications receiving 24659 citations. Previous affiliations of Sebastian Bonhoeffer include University of Oxford & École Polytechnique Fédérale de Lausanne.
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Journal ArticleDOI
Viral dynamics in human immunodeficiency virus type 1 infection
Xiping Wei,Sajal Ghosh,Maria E. Taylor,Victoria A. Johnson,Emilio A. Emini,Deutsch Paul J,Jeffrey D. Lifson,Sebastian Bonhoeffer,Martin A. Nowak,Beatrice H. Hahn,Michael S. Saag,George M. Shaw +11 more
TL;DR: Almost complete replacement of wild-type virus in plasma by drug-resistant variants occurs after fourteen days, indicating that HIV-1 viraemia is sustained primarily by a dynamic process involving continuous rounds of de novo virus infection and replication and rapid cell turnover.
Journal ArticleDOI
Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.
Graham S. Ogg,Xia Jin,Sebastian Bonhoeffer,P R Dunbar,Martin A. Nowak,Simon Monard,Jeremy P. Segal,Yunzhen Cao,Sarah Rowland-Jones,Vincenzo Cerundolo,Arlene Hurley,M. Markowitz,David D. Ho,Douglas F. Nixon,Andrew J. McMichael +14 more
TL;DR: With the use of the tetrameric complexes, a significant inverse correlation was observed between HIV-specific CTL frequency and plasma RNA viral load and suggest a considerable cytopathic effect of the virus in vivo.
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Cooperation and Competition in the Evolution of ATP-Producing Pathways
TL;DR: It is shown that ATP production with a low rate and high yield can be viewed as a form of cooperative resource use and may evolve in spatially structured environments and argued that the high ATP yield of respiration may have facilitated the evolutionary transition from unicellular to undifferentiated multicellular organisms.
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Viral dynamics in hepatitis B virus infection
Martin A. Nowak,Sebastian Bonhoeffer,Andrew M. Hill,Richard Boehme,Howard C. Thomas,Hugh McDade +5 more
TL;DR: The total daily production of plasma virus is, on average, higher in chronic HBV carriers than in HIV-infected patients, but the half-life of virus-producing cells is much shorter in HIV.
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Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection
Michael R. Betts,David R. Ambrozak,Daniel C. Douek,Sebastian Bonhoeffer,Jason M. Brenchley,Joseph P. Casazza,Richard A. Koup,Louis J. Picker +7 more
TL;DR: Overall frequencies of HIV-specific T cells are not the sole determinant of immune-mediated protection in HIV-infection, and a positive correlation was identified between the plasma viral load and the total HIV-, Env-, and Nef-specific CD8+ T-cell frequency.