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介绍了Kirk—Othmer Encyclopedia of Chemical Technology（化工技术百科全书）（第五版）电子图书网络版数据库，并对该数据库使用方法和检索途径作出了说明，且结合实例简单地介绍了该数据库的检索方法。

Kirk-Othmer Encyclopedia of Chemical Technology数据库介绍及实例

A novel series of substituted 4,6-dimethyl-2-oxo-1-(thiazol-2-ylamino)-1,2-dihydropyridine-3-carbonitrile derivatives 6, 9, 13, 15, and 17 was synthesized in a good to excellent yield from the reaction of 1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)thiourea with 2-oxo-N'-arylpropanehydrazonoyl chloride, chloroacetone, α-bromoketones, ethyl chloroacetate, and 2,3-dichloroquinoxaline, respectively. The potential DNA gyrase inhibitory activity was examined using in silico molecular docking simulation. The novel thiazoles exhibit dock score values between − 6.4 and − 9.2 kcal/mol and they were screened for their antimicrobial activities. Compound 13a shown good antibacterial activities with MIC ranged from 93.7–46.9 μg/mL, in addition, it shown good antifungal activities with MIC ranged from 7.8 and 5.8 μg/mL.

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Design, synthesis and docking studies of novel thiazole derivatives incorporating pyridine moiety and assessment as antimicrobial agents.

Providing materials with smart functionalities such as self-healing properties is primarily a domain for organic materials, although their applicability is restricted to mild environments and loads...

Smart Functionalization of Ceramic-Coated AZ31 Magnesium Alloy.

A series of new thiazolopyrimidine analogues were conveniently synthesized by one-pot multicomponent condensation reaction of ethyl acetoacetate, 2-aminothiazole and benzaldehyde substituted with different electron-donating and electron-withdrawing groups, in order to find some more potent antidiabetic and antibacterial drugs. The structures of the synthesized compounds were assigned based on elemental analyses and spectral data. An in vitro effect on total serum concentration of glucose, cholesterol and triglycerides was evaluated in adult male BALB/c mice, compared to two standard drugs “alloxan” and “glibenclamide,” and good results were observed with the presence of –Cl and –Br groups at the para position of the phenyl ring. The antibacterial activities were tested against five bacterial strains, Micrococcus luteus, Salmonella typhimurium, Bacillus subtilis, Bordetella bronchiseptica and Escherichia coli. Most of the compounds showed good to excellent bacterial zone inhibition compared to the reference drug “kanamycin.” An in silico molecular docking was also performed on synthesized compounds to support the experimental findings, which were in good agreement with computational results. The current study is expected to provide useful insights into the design of antidiabetic and antibacterial drugs, and understanding the mechanism by which such drugs interact with RNA and diabetes targets and exert their biochemical action.

Synthesis, molecular docking and biological evaluation of new thiazolopyrimidine carboxylates as potential antidiabetic and antibacterial agents

Mesogenic materials incorporating 4H-1,2,4-triazol-3-thiol moiety: Synthesis, characterization and liquid crystals study

The design, synthesis, and characterization of a star shaped 2,4,6-tris-(4`-carboxyphenoxy)-1,3,5-triazine liquid crystalline with columnar discotic mesophase properties establish H-bond interactio...

Supramolecular columnar discotic nematic liquid crystal by hydrogen bonding: Synthesis and characterization

The synthesis, characterization and mesomorphic properties of two new series of triazine-core based liquid crystals have been investigated. The amino triazine derivatives were characterized by elem...

A New Series of Triazine-core Based Mesogenic Derivatives: Synthesis, Characterization and Mesomorphic Study

Synthesis, characterization and liquid crystalline properties of novel benzimidazol-8-hydroxyquinoline complexes

A new two series of liquid crystalline Schiff bases containing thiazole moiety with different length of alkoxy spacer were synthesized, and the relation between the spacer length and the liquid crystalline behavior was investigated. The molecular structures of these compounds were performed by elemental analysis and FTIR, 1HNMR spectroscopy. The liquid crystalline properties were examined by hot stage optical polarizing microscopy (OPM) and differential scanning calorimetry (DSC). All compouns of the two series display liquid crystalline nematic mesophase. The liquid crystalline behaviour has been analyzed in terms of structural property relationship. Keywords: Thiazole, Liquid crystal, Heterocyclic, Schiff base

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Nisreen H. Karam

Papers

Mesogenic materials incorporating 4H-1,2,4-triazol-3-thiol moiety: Synthesis, characterization and liquid crystals study

Supramolecular columnar discotic nematic liquid crystal by hydrogen bonding: Synthesis and characterization

A New Series of Triazine-core Based Mesogenic Derivatives: Synthesis, Characterization and Mesomorphic Study

Synthesis, characterization and liquid crystalline properties of novel benzimidazol-8-hydroxyquinoline complexes

Synthesis and Characterization of New Derivatives of Thiazole with Liquid Crystalline properties