N
Noam A. Cohen
Researcher at University of Pennsylvania
Publications - 265
Citations - 16989
Noam A. Cohen is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Innate immune system & Taste receptor. The author has an hindex of 53, co-authored 245 publications receiving 14077 citations. Previous affiliations of Noam A. Cohen include Medical University of South Carolina & Sun Yat-sen University.
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Journal ArticleDOI
The Role of Bitter and Sweet Taste Receptors in Upper Airway Immunity.
TL;DR: The present review discusses taste receptor-protective responses and analyzes the role these receptors play in mediating airway immune function.
Journal ArticleDOI
The Effect of Drugs and Other Compounds on the Ciliary Beat Frequency of Human Respiratory Epithelium
TL;DR: Organisms, toxins, and drug excipients tend to show a cilioinhibitory effect, whereas substances in all other categories had mixed effects.
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Taste Receptors: Regulators of Sinonasal Innate Immunity
TL;DR: This review will focus on the function of bitter andSweet taste receptors in the human airway, with particular emphasis on T2R38, a bitter taste receptor found in sinonasal ciliated cells, and the bitter and sweet receptors found on specialized sinonASal solitary chemosensory cells.
Journal ArticleDOI
Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism
Li-Yin Hung,Debasish Sen,Taylor K. Oniskey,Jeremey Katzen,Noam A. Cohen,Andrew E. Vaughan,Wildaliz Nieves,Anatoly Urisman,Michael F. Beers,Matthew F. Krummel,De’Broski R. Herbert +10 more
TL;DR: It is demonstrated that lung macrophages rely upon Trefoil factor 2 to promote epithelial proliferation following damage caused by sterile wounding, Nippostrongylus brasiliensis or Bleomycin sulfate and the presence of T, B, or ILC populations was not essential for macrophage-driven repair.
Journal ArticleDOI
Molecular modulation of airway epithelial ciliary response to sneezing
Ke-Qing Zhao,Andrew T. Cowan,Robert J. Lee,Natalia Goldstein,Natalia Goldstein,Karla Droguett,Bei Chen,Chunquan Zheng,Manuel Villalón,James N. Palmer,James L. Kreindler,Noam A. Cohen,Noam A. Cohen +12 more
TL;DR: Apical ATP release with subsequent calcium mobilization and PKA activation are involved in sinonasal ciliary response to sneezing, which is blunted in patients with upper‐airway disease and surgical specimens derived from patients with chronic rhinosinusitis are observed.