Rate of depurination of native deoxyribonucleic acid.

RNA chaperones and the RNA folding problem.

Sporulation of Bacillus subtilis

https://science.sciencemag.org/content/sci/150/3704/1684.full.pdf

Health, Education, and Welfare.

Genetic aspects of bacterial endospore formation.

Deoxyribonucleic acid replication in meiosis of Chlamydomonas reinhardi. I. Isotopic transfer experiments with a strain producing eight zoospores.

Synchronous and Dichotomous Replications of the Bacillus subtilis Chromosome During Spore Germination

Publisher Summary This chapter explores that cell differentiation involves drastic changes in cell metabolism. Thus, the synthesis of many proteins is stopped and that of new ones has begun. This type of regulation could be called macroregulation in contrast to microregulation, in which the synthesis of a particular protein, or set of proteins in an operon, is specifically regulated by induction and repression. The chapter deals with the possibility of tRNA involvement as a critical factor in cell differentiation at the macroregulation level. Various mechanisms for macroregulation can be visualized. The translation of mRNA into protein involves various components, such as ribosomes, initiation and termination factors, chain elongation factors, tRNA and aminoacyl-tRNA synthetase. Among these components for code translation, tRNA is the one most likely to be involved in macroregulation because of the unique feature of being multiple for each amino acid and yet ubiquitous for the synthesis of various proteins of the cell. Controls are likely to be operating at both levels. Degeneracy of the code and degeneracy of corresponding adaptors (tRNA) have been established. On the other hand, there is generally a single aminoacyl-tRNA synthetase for each amino acid in bacteria, although, some contradictory results have been reported. In higher organisms, the mitochondria1 system seems to have its own synthetases and tRNA's in addition to cytoplasmic synthetases and tRNA's.

Noboru Sueoka

Papers

Deoxyribonucleic acid replication in meiosis of Chlamydomonas reinhardi. I. Isotopic transfer experiments with a strain producing eight zoospores.

Synchronous and Dichotomous Replications of the Bacillus subtilis Chromosome During Spore Germination

Transfer RNA and cell differentiation.

Sequential replication of the Bacillus subtilis chromosome: IV. Genetic mapping by density transfer experiment

Chromosomal location of antibiotic resistance markers in Bacillus subtilis.