Nobuyuki Takahashi

TL;DR: It is suggested that pitavastatin possesses an adiponectin-dependent antiatherosclerotic effect, and this drug is able to enhance the anti-platelet effect of EPA, and the combination therapy of pitvastatin and EPA may be beneficial for the prevention of vascular complication in hyperlipidemic patients with type II diabetes.

TL;DR: Cardiac VEGF-KDR/flk-1 system is upregulated by IL-1βvia activation of tyrosine kinases, suggesting that the IL- 1β-modulated autocrine and/or paracrine system of V EGF has an important role in the process of angiogenesis in ischemic hearts.

TL;DR: Despite no difference in the extent of myocardial necrosis and the number of coronary vessels diseased between NIDDM and nondiabetic patients, regional EF of the noninfarcted area and P/V were significantly lower when left ventricular EDV increased in NID DM patients compared with nondi diabetic patients.

TL;DR: Multivariate analysis was used to assess the clinical settings associated with the occurrence of AF in patients with their first Q-wave inferior AMI, and it was hypothesized that hemodynamic impairment, audible pericardial friction rub, electrocardiographic evidence of right ventricular AMI and age may be important clinical factors associated with that of AF.

TL;DR: In this article, a new ATR-based chemotherapy drug, M4344, was proposed and compared with the clinically developed ATR inhibitors BAY1895344, berzosertib, and ceralasertib using in vitro and in vivo models.