N
Noël F. Rosenthal
Researcher at Harvard University
Publications - 4
Citations - 146
Noël F. Rosenthal is an academic researcher from Harvard University. The author has contributed to research in topics: TaqMan & Multiple displacement amplification. The author has an hindex of 4, co-authored 4 publications receiving 134 citations.
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Antiestrogen-resistant subclones of MCF-7 human breast cancer cells are derived from a common monoclonal drug-resistant progenitor
Kathryn R. Coser,Ben S. Wittner,Noël F. Rosenthal,Sabrina C. Collins,Antonia Melas,Shannon Smith,Crystal J. Mahoney,Keiko Shioda,Kurt J. Isselbacher,Sridhar Ramaswamy,Toshi Shioda +10 more
TL;DR: The results suggest that the T/F-sublines are derived from a common monoclonal progenitor that lost transcriptomal responsiveness to antiestrogens as a consequence of genetic abnormalities many population doublings ago, not from the antiestrogen-sensitive cells in the same culture during the exposure toAntiestrogens.
Journal ArticleDOI
Masculine Epigenetic Sex Marks of the CYP19A1/Aromatase Promoter in Genetically Male Chicken Embryonic Gonads Are Resistant to Estrogen-Induced Phenotypic Sex Conversion
TL;DR: This study suggests that the epigenetic sex of chicken embryonic gonads is more stable than the morphologically or transcriptionally characterized sex differentiation, suggesting the importance of the nucleotide base-level epigeneticsex in gonadal sex differentiation.
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Expressomal approach for comprehensive analysis and visualization of ligand sensitivities of xenoestrogen responsive genes.
Toshi Shioda,Noël F. Rosenthal,Kathryn R. Coser,Mizuki Suto,Mukta Phatak,Mario Medvedovic,Vincent J. Carey,Vincent J. Carey,Kurt J. Isselbacher +8 more
TL;DR: This study provides a conceptual and methodological framework for the systematic examination of gene sensitivities and demonstrates effective detection of nonmonotonic dose-dependent responses, introducing the importance of gene sensitivity analysis to pharmacogenomic and toxicogenomic research.
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High-throughput applicable genomic sex typing of chicken by TaqMan real-time quantitative polymerase chain reaction
TL;DR: The TaqMan typing of chicken genetic sex has several advantageous features for high-throughput operation compared with conventional methods, including real-time amplification curves of the quantitative PCR reaction that readily distinguished truly homozygous and heterozygous sex chromosomes from contamination of the sex chromosomal DNA.