N
Noriaki Ohnishi
Researcher at Kyoto Pharmaceutical University
Publications - 61
Citations - 1016
Noriaki Ohnishi is an academic researcher from Kyoto Pharmaceutical University. The author has contributed to research in topics: Pirarubicin & Pharmacokinetics. The author has an hindex of 18, co-authored 61 publications receiving 978 citations.
Papers
More filters
Journal ArticleDOI
EXPRESSION PROFILES OF DRUG-METABOLIZING ENZYME CYP3A AND DRUG EFFLUX TRANSPORTER MULTIDRUG RESISTANCE 1 SUBFAMILY mRNAS IN RAT SMALL INTESTINE
TL;DR: It was suggested that drug metabolism in the small intestine of normal rats was mediated by CYP 3A9 and CYP3A18 rather than CYP2A1 and CYp3A2 rather than CyP3a1 and CyP2, suggesting the cooperative action of drug clearance pathways.
Journal ArticleDOI
Studies on Interactions between Functional Foods or Dietary Supplements and Medicines.I. Effects of Ginkgo biloba Leaf Extract on the Pharmacokinetics of Diltiazem in Rats
Noriaki Ohnishi,Mayako Kusuhara,Mutsunobu Yoshioka,Kazuo Kuroda,Akihiro Soga,Fumi Nishikawa,Tomokazu Koishi,Masato Nakagawa,Satoshi Hori,Tsuyoshi Matsumoto,Masayuki Yamashita,Shunsaku Ohta,Koji Takara,Teruyoshi Yokoyama +13 more
TL;DR: Results indicated that the concomitant use of GBE in rats increased the bioavailability of DTZ by inhibiting both intestinal and hepatic metabolism, at least in part, via a mechanism-based inhibition for CYP3A.
Journal ArticleDOI
Effects of 19 herbal extracts on the sensitivity to paclitaxel or 5-fluorouracil in HeLa cells
TL;DR: Findings indicate that the combination of anticancer drugs with some herbal extracts contributes to the enhancement of clinical outcomes in cancer chemotherapy.
Journal ArticleDOI
Studies on interactions between functional foods or dietary supplements and medicines. IV. Effects of ginkgo biloba leaf extract on the pharmacokinetics and pharmacodynamics of nifedipine in healthy volunteers.
Mutsunobu Yoshioka,Noriaki Ohnishi,Tomokazu Koishi,Yukihisa Obata,Masato Nakagawa,Tsuyoshi Matsumoto,Kentaro Tagagi,Koji Takara,Tsuyoshi Ohkuni,Teruyoshi Yokoyama,Kazuo Kuroda +10 more
TL;DR: It was concluded that GBE and NFP should not be simultaneously ingested as much as possible, and careful monitoring is needed when administering NFP concomitantly with GBE to humans.
Journal ArticleDOI
Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression.
Kohji Takara,Toshiyuki Sakaeda,Yusuke Tanigawara,Kohshi Nishiguchi,Nobuko Ohmoto,Masanori Horinouchi,Fusao Komada,Noriaki Ohnishi,Teruyoshi Yokoyama,Katsuhiko Okumura +9 more
TL;DR: It is concluded that Ca(2+) antagonists cannot only be direct inhibitors of MDR1 but that some may at the same time act as inhibitors of expression ofMDR1 via down-regulation of M DR1 mRNA.