N
Noriyuki Yamamoto
Researcher at Bayer
Publications - 40
Citations - 689
Noriyuki Yamamoto is an academic researcher from Bayer. The author has contributed to research in topics: Overactive bladder & Urinary incontinence. The author has an hindex of 12, co-authored 40 publications receiving 666 citations. Previous affiliations of Noriyuki Yamamoto include Gifu Pharmaceutical University & Bayer Corporation.
Papers
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Journal ArticleDOI
The Orally Available Spleen Tyrosine Kinase Inhibitor 2-[7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide Dihydrochloride (BAY 61-3606) Blocks Antigen-Induced Airway Inflammation in Rodents
Noriyuki Yamamoto,Keisuke Takeshita,Michitaka Shichijo,Toshio Kokubo,Masako Sato,Kosuke Nakashima,Mina Ishimori,Hiroichi Nagai,Li Yingfu,Takeshi Yura,Kevin Bacon +10 more
TL;DR: It was demonstrated that Syk may play a very critical role in the pathogenesis of allergic reactions and was identified as a potent and selective inhibitor of Syk kinase.
Patent
Imidazopyrimidine derivatives and triazolopyrimidine derivatives
Takeshi Yura,Concepcion Arnel B,Han Gyoonhee,Hiraoka Makiko,Katsumata Hiroko,Kawamura Norihiro,Toshio Kokubo,Komura Hiroshi,Li Yingfu,Lowinger Timothy B,Muneto Mogi,Noriyuki Yamamoto,Nagahiro Yoshida,Scott Miller,Popp Margaret A,Redmann Aniko M,Rodriguez Martha E,William J. Scott,Ming Wang +18 more
TL;DR: A compound of the formula (I) wherein R 1 is -X-R4, an optionally substituted heterocyclic residue, a optionally substituted carbcycle residue or optionally substituted condensed ring moiety; X is CR5R6, O, S, SO, SO?2? or NR?7?; Y is CH or N; R 2 is H, an alternatively substituted C?1?-C10 alkyl, etc as discussed by the authors.
Journal ArticleDOI
Inhibition of Syk Activity and Degranulation of Human Mast Cells by Flavonoids
Michitaka Shichijo,Noriyuki Yamamoto,Hideki Tsujishita,Masahiro Kimata,Hiroichi Nagai,Toshio Kokubo +5 more
TL;DR: The results suggested that the impairment of mast cell degranulation by several flavonoids classified into flavones and flavonols might be mediated via inhibition of the intracellular activation of Syk.
Patent
Tetrahydro-naphthalene and urea derivatives
Axel Dr. Bouchon,Nicole Diedrichs,Achim Hermann,Klemens Lustig,Heinrich Meier,Josef Pernerstorfer,Elke Reissmüller,Muneto Mogi,Takeshi Yura,Hiroshi Fujishima,Masanori Seki,Yuji Koriyama,Kayo Yasoshima,Keiko Misawa,Masaomi Tajimi,Noriyuki Yamamoto,Klaus Urbahns,Fumihiko Hayashi,Yasuhiro Tsukimi,Jang Bahadur Gupta +19 more
TL;DR: In this paper, the authors defined an urea derivative formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations, wherein A represents formula (II) or (III) wherein n represents the connection position to the molecule and Q1a, Q2a, q3a and q4a are defined.
Journal ArticleDOI
Functional role of prostacyclin receptor in rat dorsal root ganglion neurons.
Koichi Nakae,Fumihiko Hayashi,Mayumi Hayashi,Noriyuki Yamamoto,Takashi Iino,Satoru Yoshikawa,Jang Bahadur Gupta +6 more
TL;DR: Iloprost was the most potent agonist to induce cAMP accumulation and SP release among prostanoid agonists evaluated in this study and its effect is mediated by IP receptor, which strongly indicates that IP receptor play an important role in the sensitization of rat sensory neuron.