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Nuria M. Vivas
Researcher at Autonomous University of Barcelona
Publications - 32
Citations - 986
Nuria M. Vivas is an academic researcher from Autonomous University of Barcelona. The author has contributed to research in topics: Tacrine & Huperzine A. The author has an hindex of 17, co-authored 32 publications receiving 944 citations. Previous affiliations of Nuria M. Vivas include University of Barcelona.
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Journal ArticleDOI
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
Pelayo Camps,El Achab R,Jordi Morral,Diego Muñoz-Torrero,Albert Badia,Josep-Eladi Baños,Nuria M. Vivas,Xavier Barril,Modesto Orozco,Francisco J. Luque +9 more
TL;DR: Molecular modeling simulations of the AChE-inhibitor complex provided a basis to explain the differences in inhibitory activity of these compounds and supported the tight-binding character of compounds (-)-20 and (-)-30 and showed their ability to cross the blood-brain barrier.
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Assessing the (a)symmetry of concentration-effect curves: empirical versus mechanistic models
TL;DR: In this article, a survey of empirical and mechanistic models for the shape of concentration-effect curves is presented, including the modified Hill equation, the Richards function, and the Gompertz model.
Journal ArticleDOI
Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease
Pelayo Camps,R. El Achab,D M Görbig,Jordi Morral,Diego Muñoz-Torrero,A. Badia,J Eladi Baños,Nuria M. Vivas,Xavier Barril,Modesto Orozco,Francisco J. Luque +10 more
TL;DR: Molecular modeling of the interaction of these compounds with AChE from Torpedo californica showed them to interact as truly THA-huperzine A hybrids: the 4-aminoquinoline subunit of (-)-19 occupies the same position of the corresponding subunit in THA, while its bicyclo.
Journal ArticleDOI
Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.
Albert Badia,Josep E. Baños,Pelayo Camps,Joan Contreras,Diana Marina Gorbig,Diego Muñoz-Torrero,Montserrat Simon,Nuria M. Vivas +7 more
TL;DR: Derivatives 7dy and 7ey, lacking the ethylidene substituent, showed to be more active than tacrine in reversing the partial neuromuscular blockade induced by d-tubocurarine.
Journal ArticleDOI
Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of new tacrine-like analogues.
José L. Marco,Cristóbal de los Ríos,Maria do Carmo Carreiras,Josep E. Baños,Albert Badia,Nuria M. Vivas +5 more
TL;DR: The synthesis and preliminary results for acetylcholinesterase and butyrylcholine inhibition activity of a series of pyrano[2,3-b]quinolines and benzonaphthyridines derivatives are described, with the more potent compounds being 6 times less active than tacrine.