The stages of initiation and promotion in hepatocarcinogenesis.

Hepatocellular glycogenosis and hepatocarcinogenesis

Hepatocellular glycogenosis and related pattern of enzymatic changes during hepatocarcinogenesis

The natural history of carcinogenesis: implications of experimental carcinogenesis in the genesis of human cancer.

The morphology of hepatocellular carcinoma is similar among mice, rats and humans, and the cellular pathogenesis shows features that are both similar and divergent among these species. However, major elements of etiology, molecular pathogenesis, and natural history differ between humans and rodents. As a reflection of these species-determined differences, rodents appear to be neither highly sensitive nor highly specific surrogates for detecting agents that are potential causes of hepatocellular cancer in humans. Results of tests of chemical carcinogenicity in rodents are likely to include a significant number of both false-positive and false-negative risks for humans.

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Interspecies comparison of liver carcinogenesis: implications for cancer risk assessment

Die Gultigkeit experimentell begrundeter Vorstellungen uber die Morphogenese der Leberkrebszelle fur die Humanpathologie wird an Biopsien von 12 hepatocellularen Carcinomen und 5 Adenomen licht- und z.T. auch elektronenmikroskopisch gepruft. Die Ergebnisse belegen, das der Gestaltwandel der Hepatocyten wahrend der Carcinogenese bei Mensch und Versuchstier prinzipiell ubereinstimmt: In beiden Fallen besteht offenbar eine enge Beziehung zwischen hepatocellularer Glykogenose und Hepatombildung.

O. Klinge

Papers

Hepatocelluläre Glykogenose und Hepatombildung beim Menschen