Journal ArticleDOI
Hepatocelluläre Glykogenose und Hepatombildung beim Menschen
P. Bannasch,O. Klinge +1 more
- Vol. 352, Iss: 2, pp 157-164
TLDR
In this article, the Gestaltwandel der Hepatocyten wahrend der Carcinogenese bei Mensch und Versuchstier prinzipiell ubereinstimmt.Abstract:
Die Gultigkeit experimentell begrundeter Vorstellungen uber die Morphogenese der Leberkrebszelle fur die Humanpathologie wird an Biopsien von 12 hepatocellularen Carcinomen und 5 Adenomen licht- und z.T. auch elektronenmikroskopisch gepruft. Die Ergebnisse belegen, das der Gestaltwandel der Hepatocyten wahrend der Carcinogenese bei Mensch und Versuchstier prinzipiell ubereinstimmt: In beiden Fallen besteht offenbar eine enge Beziehung zwischen hepatocellularer Glykogenose und Hepatombildung.read more
Citations
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Journal ArticleDOI
The stages of initiation and promotion in hepatocarcinogenesis.
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Hepatocellular glycogenosis and hepatocarcinogenesis
Journal ArticleDOI
Hepatocellular glycogenosis and related pattern of enzymatic changes during hepatocarcinogenesis
TL;DR: Systematic studies of the sequence of cellular changes during hepatocarcinogenesis induced predominantly in rats by stop experiments with N-nitrosomorpholine led to the following main results and conclusions: the development of hepatocellular tumors is preceded by a multifocal hepatic glycogen storage disease (glycogenosis).
Journal ArticleDOI
The natural history of carcinogenesis: implications of experimental carcinogenesis in the genesis of human cancer.
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Interspecies comparison of liver carcinogenesis: implications for cancer risk assessment
TL;DR: The morphology of hepatocellular carcinoma is similar among mice, rats and humans, and the cellular pathogenesis shows features that are both similar and divergent among these species.
References
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Journal Article
Cellular Analysis of Liver Carcinogenesis: the Induction of Large Hyperplastic Nodules in the Liver with 2-Fluorenylacetamide or Ethionine and Some Aspects of Their Morphology and Glycogen Metabolism
TL;DR: A dietary regimen is described whereby large hyperplastic nodules can be obtained in over half the rats fed either of the two hepatocarcinogens, ethionine or 2-fluorenylacetamide, which shows morphologic and biochemical differences from the surrounding nonhyperplastic liver.
Journal ArticleDOI
Primary Carcinoma of the Liver in Childhood: An Epidemiologic Study
Journal ArticleDOI
Enzyme histochemical and radioautographic studies during cancerization of the rat liver with diethylnitrosamine
A. Schauer,E. Kunze +1 more
TL;DR: Kinetische autoradiographische Untersuchungen haben gezeigt, das sich nach 45 min radioaktiver Versuchszeit die H3-Cytidinmarkierung fast ausschlieslich uber dem Zellkern findet, wahrend nach 140 min die Markierung im Cytoplasma erheblich zugenommen hat.
Journal ArticleDOI
Histochemische Untersuchungen der Cancerogenese in der Rattenleber nach Dauergaben von Diäthylnitrosamin
TL;DR: In this paper, weiblichen Ratten (Sprague-Dawley) Diathylnitrosamin was verabfolgt in 4 verschiedenen Dosierungen.
Journal ArticleDOI
Glycogen disease of the liver (von Gierke's disease) with hepatomata; case report with metabolic studies.
TL;DR: The child was dwarfed and mentally retarded, followed from the age of 6 months to death at 10½ years, and the terminal illness was marked by 2 unexplained complications: multiple hepatomata and congestive right heart failure.
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Enzyme histochemical and radioautographic studies during cancerization of the rat liver with diethylnitrosamine
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