O
O'toole John Cunningham
Researcher at Eli Lilly and Company
Publications - 10
Citations - 260
O'toole John Cunningham is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Stereoselectivity & Acetonitrile. The author has an hindex of 6, co-authored 10 publications receiving 248 citations.
Papers
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Journal ArticleDOI
Substituted 3-imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino-[6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as highly selective and potent inhibitors of glycogen synthase kinase-3.
Thomas A. Engler,Henry,Sushant Malhotra,Brian Eugene Cunningham,Kelly Wayne Furness,Joseph T. Brozinick,Burkholder Timothy P,Michael P. Clay,Joshua Ryan Clayton,Clive Gideon Diefenbacher,Eric D. Hawkins,Philip W. Iversen,YiHong Burlingame Li,Terry D. Lindstrom,Angela Lynn Marquart,Mclean Johnathan Alexander,David Mendel,Elizabeth A. Misener,Daniel A. Briere,O'toole John Cunningham,Warren J. Porter,Queener S,Jon K. Reel,Owens Rebecca Anne,Richard A. Brier,Thomas E Eessalu,Wagner,Robert M. Campbell,Vaughn R +28 more
TL;DR: A series of potent and selective GSK3 inhibitors are discovered, 7-12 show oral activity in an in vivo model of type II diabetes, and 9 and 12 have desirable PK properties.
Journal ArticleDOI
The development of potent and selective bisarylmaleimide GSK3 inhibitors.
Thomas A. Engler,Sushant Malhotra,Burkholder Timothy P,Henry James Robert,David Mendel,Warren J. Porter,Kelly Wayne Furness,Clive Gideon Diefenbacher,Angela Lynn Marquart,Jon K. Reel,Yihong Li,Joshua Ryan Clayton,Brian Eugene Cunningham,Mclean Johnathan Alexander,O'toole John Cunningham,Joseph T. Brozinick,Eric D. Hawkins,Elizabeth A. Misener,Daniel A. Briere,Richard A. Brier,Jill R. Wagner,Robert M. Campbell,Bryan D. Anderson,Renee Vaughn,Donald B. Bennett,Timothy I. Meier,James A. Cook +26 more
TL;DR: These compounds inhibited tau phosphorylation in cells and were effective in lowering plasma glucose in a rat model of type 2 diabetes (ZDF rat) with >160 to >10,000-fold selectivity versus CDK2/4 and PKCbetaII.
Journal ArticleDOI
An efficient and practical synthesis of diphenyl cyanomethylenephosphonate: Applications to the stereoselective synthesis of cis-α,β-unsaturated nitriles
TL;DR: Diphenyl cyanomethylenephosphonate (PhO)2POCH2CN was prepared as a stable crystalline solid in high yield in a single step from acetonitrile, LDA, and PhO 2P(O)Cl as mentioned in this paper.
Patent
6-arylalkylamino- 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
Karin Briner,Adeva Bartolome Marta,Manuel Javier Cases-Thomas,Christopher Stanley Galka,Llorente Alicia Marcos,Maria Angeles Martinez-Grau,Michael Philip Mazanetz,O'toole John Cunningham,Richard E. Rathmell,Reinhard Matthew Robert,Sapmaz Selma,Andrew Caerwyn Williams +11 more
TL;DR: In this paper, a 6-substituted 2,3,4,5,tetrahydro-lH- benzo[d]azepines of Formula (I) were used as selective 5-HT2c receptor agonists for the treatment of obesity, obsessive/compulsive disorder, depression, and anxiety.
Patent
Arylpiperazines having activity at the serotonin 1A receptor
Godfrey Alexander Glenn,Daniel Timothy Kohlman,O'toole John Cunningham,Xu Yao-Chang,Tony Y. Zhang +4 more
TL;DR: Arylpiperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal as discussed by the authors.