O
Olga Horakova
Researcher at Academy of Sciences of the Czech Republic
Publications - 21
Citations - 1102
Olga Horakova is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Adipose tissue & Polyunsaturated fatty acid. The author has an hindex of 9, co-authored 18 publications receiving 985 citations.
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Journal ArticleDOI
Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat.
Pavel Flachs,Olga Horakova,Petr Brauner,Martin Rossmeisl,Petr Pecina,N. Franssen van Hal,Jana Ruzickova,Jana Sponarova,Zdeněk Drahota,C. Vlcek,Jaap Keijer,Josef Houstek,Jan Kopecky +12 more
TL;DR: The anti-adipogenic effect of EPA/DHA may involve a metabolic switch in adipocytes that includes enhancement of β-oxidation and upregulation of mitochondrial biogenesis.
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Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet.
Pavel Flachs,Vidya Mohamed-Ali,Olga Horakova,Martin Rossmeisl,Mohammad Javad Hosseinzadeh-Attar,M Hensler,Jana Ruzickova,Jan Kopecky +7 more
TL;DR: Intake of diets rich in EPA and DHA leads to elevated systemic concentrations of adiponectin, largely independent of food intake or adiposity and explain, to some extent, their anti-diabetic effects.
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Metformin acutely lowers blood glucose levels by inhibition of intestinal glucose transport
Olga Horakova,Petra Kroupova,Kristina Bardova,Jana Buresova,Petra Janovska,Jan Kopecky,Martin Rossmeisl +6 more
TL;DR: The results support the view that the inhibition of transepithelial glucose transport in the intestine is responsible for lowering blood glucose levels during an early response to oral administration of metformin.
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Preservation of Metabolic Flexibility in Skeletal Muscle by a Combined Use of n-3 PUFA and Rosiglitazone in Dietary Obese Mice
Olga Horakova,Dasa Medrikova,Evert M. van Schothorst,Annelies Bunschoten,Pavel Flachs,Vladimir Kus,Ondrej Kuda,Kristina Bardova,Petra Janovska,M Hensler,Martin Rossmeisl,Rui Wang-Sattler,Cornelia Prehn,Jerzy Adamski,Thomas Illig,Jaap Keijer,Jan Kopecky +16 more
TL;DR: The results further support the idea that the combined use of n-3 LC-PUFA and TZDs could improve the efficacy of the therapy of obese and diabetic patients.
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Involvement of AMP-activated protein kinase in fat depot-specific metabolic changes during starvation.
Jana Sponarova,Kirsty J. Mustard,Olga Horakova,Pavel Flachs,Martin Rossmeisl,Petr Brauner,Kristina Bardova,Michaela Thomason-Hughes,Radka Braunerova,Petra Janovska,D. Grahame Hardie,Jan Kopecky +11 more
TL;DR: The results suggest that AMPK may have a role in the different response of various fat depots to starvation, and in epididymal fat, relatively strong upregulation of uncoupling protein 2 and phosphoenolpyruvate carboxykinase genes was found.