O
Olga V. Kretova
Researcher at Engelhardt Institute of Molecular Biology
Publications - 30
Citations - 409
Olga V. Kretova is an academic researcher from Engelhardt Institute of Molecular Biology. The author has contributed to research in topics: Gene & RNA interference. The author has an hindex of 11, co-authored 30 publications receiving 359 citations.
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Journal ArticleDOI
Hot spots of DNA double-strand breaks and genomic contacts of human rDNA units are involved in epigenetic regulation
Nickolai A. Tchurikov,D. M. Fedoseeva,Dmitri V. Sosin,A V Snezhkina,Nataliya V. Melnikova,Anna V. Kudryavtseva,Yuri V. Kravatsky,Olga V. Kretova +7 more
TL;DR: Mapping of hot spots of DSBs in a human 43-kb ribosomal DNA (rDNA) repeated unit suggests a strong link between chromosome breakage and several different mechanisms of epigenetic regulation of gene expression.
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Sensitivity of acute myeloid leukemia Kasumi-1 cells to binase toxic action depends on the expression of KIT and АML1-ETO oncogenes
Vladimir A. Mitkevich,Irina Yu. Petrushanko,Pavel Spirin,Tatiana V. Fedorova,Olga V. Kretova,Nickolai A. Tchurikov,Vladimir S. Prassolov,Olga N. Ilinskaya,Alexander A. Makarov +8 more
TL;DR: Evidence is provided that the cooperative effect of the expression of mutated KIT and AML1-ETO oncogenes is crucial for selective toxic action of binase on malignant cells.
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Ribonuclease binase apoptotic signature in leukemic Kasumi-1 cells.
Vladimir A. Mitkevich,Olga V. Kretova,Irina Yu-U. Petrushanko,K. M. Burnysheva,Dmitry V. Sosin,Olga V. Simonenko,Olga N. Ilinskaya,Nickolai A. Tchurikov,Alexander A. Makarov +8 more
TL;DR: Results suggest that binase induces evolutionary acquired cellular response to a microbial agent and triggers unusual apoptosis pathway in leukemic Kasumi-1 cells.
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DNA double-strand breaks coupled with PARP1 and HNRNPA2B1 binding sites flank coordinately expressed domains in human chromosomes.
Nickolai A. Tchurikov,Olga V. Kretova,D. M. Fedoseeva,Dmitri V. Sosin,Sergei A. Grachev,Marina V. Serebraykova,Svetlana A. Romanenko,N.V. Vorobieva,Yuri V. Kravatsky +8 more
TL;DR: A novel type of gene regulation is suggested: a coordinated transcription or silencing of gene clusters delimited by DSB hot spots as well as PARP1 and HNRNPa2B1 binding sites.
Journal ArticleDOI
Evidence for RNA synthesis in the intergenic region between enhancer and promoter and its inhibition by insulators in Drosophila melanogaster
TL;DR: An approach employing transient expression of genetic luciferase reporter gene constructs with quantitative RT–PCR analysis of transcription between an enhancer and Hsp70 promoter highlights the involvement of RNA-tracking mechanisms in the communications between enhancers and promoters, which are inhibited by insulators.