O
Olivier Pineau
Researcher at GlaxoSmithKline
Publications - 5
Citations - 316
Olivier Pineau is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Angiotensin II receptor type 1 & Internal medicine. The author has an hindex of 4, co-authored 4 publications receiving 278 citations.
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Journal ArticleDOI
Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains
Olivier Mirguet,Romain Luc Marie Gosmini,Jérôme Toum,Catherine A. Clément,Mélanie Barnathan,Jean-Marie Brusq,Jacqueline Elizabeth Mordaunt,Grimes Richard Martin,Miriam Crowe,Olivier Pineau,Myriam Ajakane,Alain Claude-Marie Daugan,Phillip Jeffrey,Leanne Cutler,Andrea C. Haynes,Nicholas Smithers,Chun-wa Chung,Paul Bamborough,Iain Uings,Antonia J. Lewis,Jason Witherington,Nigel J. Parr,Rab K. Prinjha,Edwige Nicodeme +23 more
TL;DR: This work has yielded a potent, selective compound I-BET762 that is now under evaluation in a phase I/II clinical trial for nuclear protein in testis (NUT) midline carcinoma and other cancers.
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Discovery of novel indazole derivatives as dual angiotensin II antagonists and partial PPARγ agonists
Yann Lamotte,Nicolas Faucher,Julien Sançon,Olivier Pineau,Stéphane Sautet,Marie-Hélène Fouchet,Veronique Beneton,Jean-Jacques Tousaint,Yannick Saintillan,Nicolas Ancellin,Edwige Nicodeme,Didier Grillot,Paul Martres +12 more
TL;DR: Among the new compounds, 38 was identified as a potent AT1 receptor antagonist and partial PPARγ agonist with good oral bioavailability in rat and the dual pharmacology of compound 38 was demonstrated in two preclinical models of hypertension (SHR) and insulin resistance.
Journal ArticleDOI
Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor α agonists
TL;DR: Synthesis, in vitro and in vivo evaluation of the most potent compound are reported and it is reported that trifluoromethane sulfonamides as potent PPARalpha agonists are reported.
Journal ArticleDOI
The discovery of equipotent PPARα/γ dual activators
Paul Martres,Nicolas Faucher,Alain Laroze,Olivier Pineau,Marie Helene Fouchet,Florent Potvain,Didier Grillot,Veronique Beneton +7 more
TL;DR: The design and synthesis of equipotent PPARalpha/gamma dual agonists starting from selective PPAR alpha agonist 1 are reported and in vivo data for 7 in the Zucker fa/fa rat are presented.
Journal ArticleDOI
The impact of transoesophageal echocardiography in elderly patients with infective endocarditis.
M.-P. N’cho-Mottoh,Marie-Line Erpelding,Claire Roubaud,François Delahaye,T. Fraisse,Marina Dijos,Pierre Vladimir Ennezat,Arnaud Fluttaz,Corinne Beaufort,Pierre Nazeyrollas,Camille Brasselet,Olivier Pineau,Pierre Tattevin,Elodie Curlier,Bernard Iung,Emmanuel Forestier,Christine Selton-Suty +16 more
TL;DR: In this article , the authors describe transoesophageal echocardiography (TEE) use in elderly IE patients, and its impact on therapeutic management and mortality, and make comparisons between patients who did or did not undergo TEE.