O
Oscar J. M. Goddijn
Researcher at Leiden University
Publications - 9
Citations - 613
Oscar J. M. Goddijn is an academic researcher from Leiden University. The author has contributed to research in topics: Tryptamine & Catharanthus roseus. The author has an hindex of 8, co-authored 9 publications receiving 602 citations.
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Journal ArticleDOI
Coordinated regulation of two indole alkaloid biosynthetic genes from Catharanthus roseus by auxin and elicitors.
Giancarlo Pasquali,Oscar J. M. Goddijn,A. De Waal,Robert Verpoorte,R. A. Schilperoort,J. H. C. Hoge,Johan Memelink +6 more
TL;DR: Results show that a first important regulatory step in the complex process leading to indole alkaloid accumulation in C. roseus suspension cells is transcription of the biosynthetic genes.
Journal ArticleDOI
Auxin rapidly down-regulates transcription of the tryptophan decarboxylase gene from Catharanthus roseus.
TL;DR: One of the mechanisms which control the activity of terpenoid indole alkaloid biosynthesis in C. roseus cell cultures is the negative regulation by auxin of the gene involved in the first committed step of trytophan decarboxylase.
Journal ArticleDOI
Overexpression of a tryptophan decarboxylase cDNA in Catharanthus roseus crown gall calluses results in increased tryptamine levels but not in increased terpenoid indole alkaloid production
Oscar J. M. Goddijn,E. J. M. Pennings,Peter van der Helm,Rob A. Schilperoort,Robert Verpoorte,J. Harry C. Hoge +5 more
TL;DR: Hardly anytdc mRNA could be detected in hormone-independent callus and cell suspension cultures transformed by the oncogenic T-DNA of Agrobacterium tumefaciens, and supply of tryptamine may represent a limiting factor in the biosynthesis of alkaloids by such cultures.
Journal ArticleDOI
Increased production of serotonin by suspension and root cultures ofPeganum harmala transformed with a tryptophan decarboxylase cDNA clone fromCatharanthus roseus
Jochen Berlin,Christiane Rügenhagen,Peter Dietze,Lothar F. Fecker,Oscar J. M. Goddijn,J. Harry C. Hoge +5 more
TL;DR: The data demonstrate that the production of a plant secondary metabolite can be enhanced greatly via genetic manipulation of the level of activity of the rate-limiting enzyme.
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Nucleotide sequence of the tryptophan decarboxylase gene of Catharanthus roseus and expression of tdc-gusA gene fusions in Nicotiana tabacum
TL;DR: It is reported that TDC is encoded by a single copy gene in the C. roseus genome and Histochemical and fluorimetric analysis of transgenic plants revealed that 1938 by of the tdc promoter give rise to GUS activity in roots, stems and leaves.