P
P.A.E.L. Schilderman
Researcher at Maastricht University
Publications - 21
Citations - 1068
P.A.E.L. Schilderman is an academic researcher from Maastricht University. The author has contributed to research in topics: DNA damage & Butylated hydroxyanisole. The author has an hindex of 18, co-authored 21 publications receiving 1015 citations.
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Journal ArticleDOI
IN VITRO EFFECTS OF COAL FLY ASHES: Hydroxyl Radical Generation, Iron Release, and DNA Damage and Toxicity in Rat Lung Epithelial Cells
J.M.S. van Maanen,P J Borm,Ad M. Knaapen,M van Herwijnen,P.A.E.L. Schilderman,K R Smith,Ann E. Aust,Maura Tomatis,Bice Fubini +8 more
TL;DR: The data suggest that quartz in CFA does not act the same as quartz in silica or coal mine dust, and an important role for size and iron release in generation and subsequent effects of reactive oxygen species caused by CFA is indicated.
Journal ArticleDOI
Neutrophils cause oxidative DNA damage in alveolar epithelial cells.
Ad M. Knaapen,Frank Seiler,P.A.E.L. Schilderman,Peter Nehls,Joachim Bruch,Roel P. F. Schins,Paul J. A. Borm +6 more
TL;DR: Evidence is provided that ROS released by PMN as well as H2O2, cause oxidative DNA damage in epithelial cells, and inhibitor experiments showed that antioxidants ameliorated oxidativeDNA damage.
Journal ArticleDOI
Butylated hydroxyanisole in perspective
TL;DR: It is hypothesized that BHA gives rise to tumor formation in rodent forestomach by inducing heritable changes in DNA, and evidence is being provided that reactive oxygen species, in particular hydroxylradicals, may play a crucial role.
Journal ArticleDOI
Possible relevance of pigeons as an indicator species for monitoring air pollution.
P.A.E.L. Schilderman,J. A. Hoogewerff,F.J. van Schooten,L.M. Maas,Edwin J.C. Moonen,B.J.H. van Os,J. H. Van Wijnen,J.C.S. Kleinjans +7 more
TL;DR: The results indicate that wild city pigeons can be used as biological indicators of exposure to heavy metal pollution in outdoor air and that places with high and medium traffic density could be clearly discriminated on the basis of PAH levels in the ambient air.
Journal ArticleDOI
A multi-biomarker approach to study the effects of smoking on oxidative DNA damage and repair and antioxidative defense mechanisms.
A. Besarati Nia,F.J. van Schooten,P.A.E.L. Schilderman,T.M.C.M. de Kok,Guido R.M.M. Haenen,M.H.M. van Herwijnen,E. van Agen,D. M. F. A. Pachen,Jos C. S. Kleinjans +8 more
TL;DR: It is concluded that oxidative stress imposed by cigarette smoking has a low impact upon certain pathways involved in DNA damage and the antioxidative defense system.