P
P.A. Howe
Researcher at John Radcliffe Hospital
Publications - 7
Citations - 339
P.A. Howe is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Penicilliosis & Penicillium marneffei. The author has an hindex of 5, co-authored 7 publications receiving 325 citations. Previous affiliations of P.A. Howe include Mahidol University.
Papers
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Journal ArticleDOI
Comparison of imipenem and ceftazidime as therapy for severe melioidosis.
Andrew J. H. Simpson,Yupin Suputtamongkol,M. D. Smith,Brian Angus,Adul Rajanuwong,Vanaporn Wuthiekanun,P.A. Howe,Amanda L. Walsh,Wipada Chaowagul,Nicholas J. White +9 more
TL;DR: Imipenem is a safe and effective treatment for acute severe melioidosis and may be considered an alternative to ceftazidime and the main outcome measures were death or treatment failure.
Journal ArticleDOI
A prospective study of AIDS-associated cryptococcal meningitis in Thailand treated with high-dose amphotericin B
Punnee Pitisuttithum,Somsit Tansuphasawadikul,Andrew J. H. Simpson,Andrew J. H. Simpson,P.A. Howe,P.A. Howe,Nicholas J. White,Nicholas J. White +7 more
TL;DR: High-dose amphotericin B was not as effective as previously thought in treating AIDS-associated cyptococcal meningitis and prognostic factors affecting survival after high- doses followed by oral azole treatment.
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Diagnosis of Penicillium marneffei infection by quantitation of urinary antigen by using an enzyme immunoassay.
Varunee Desakorn,M. D. Smith,M. D. Smith,Amanda L. Walsh,Amanda L. Walsh,Andrew J. H. Simpson,Andrew J. H. Simpson,Duangjai Sahassananda,Adul Rajanuwong,V. Wuthiekanun,P.A. Howe,P.A. Howe,Brian Angus,Brian Angus,Pravan Suntharasamai,N J White,N J White +16 more
TL;DR: A method for the quantitation of P. marneffeiantigen in urine was developed by using fluorescein isothiocyanate-labelled purified rabbit hyperimmune immunoglobulin G in an enzyme-linked immunosorbent assay and had a diagnostic sensitivity and specificity of 97% and 98% respectively.
Journal ArticleDOI
Development and Evaluation of Rapid Urinary Antigen Detection Tests for Diagnosis of Penicilliosis Marneffei
Varunee Desakorn,Andrew J. H. Simpson,Andrew J. H. Simpson,Vanaporn Wuthiekanun,Duangjai Sahassananda,Adul Rajanuwong,Punnee Pitisuttithum,P.A. Howe,P.A. Howe,M. D. Smith,M. D. Smith,Nicholas J. White,Nicholas J. White +12 more
TL;DR: The LA test is simple, robust, rapid, and convenient and should prove to be an important addition to the existing diagnostic tests for penicilliosis.
Journal ArticleDOI
A comparison of lysis centrifugation, pour plate, and conventional blood culture methods in the diagnosis of septicaemic melioidosis.
TL;DR: Routine use of one of these quantitative methods, in addition to conventional broth culture, may lead to earlier diagnosis of septicaemic melioidosis.