P
P. Frederick Sparling
Researcher at University of North Carolina at Chapel Hill
Publications - 69
Citations - 3322
P. Frederick Sparling is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Neisseria gonorrhoeae & Transferrin. The author has an hindex of 29, co-authored 69 publications receiving 3170 citations. Previous affiliations of P. Frederick Sparling include Scripps Research Institute.
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The emerging threat of untreatable gonococcal infection.
TL;DR: During the past 3 years, the wily gonococcus has become less susceptible to the last line of antimi crobial defense, threatening the ability to cure gonorrhea and prevent severe sequelae.
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Neisseria gonorrhoeae Activates the Proteinase Cathepsin B to Mediate the Signaling Activities of the NLRP3 and ASC-Containing Inflammasome
Joseph A. Duncan,Xi Gao,Max Tze Han Huang,Brian P. O'Connor,Christopher E. Thomas,Stephen B. Willingham,Daniel T. Bergstralh,Gary A. Jarvis,P. Frederick Sparling,Jenny P.-Y. Ting +9 more
TL;DR: This work demonstrates that NLRP3 (cryopyrin, NALP3) is the primary NLR required for IL-1β/IL-18 secretion in response to N. gonorrhoeae and indicates that activation ofNLRP3-mediated inflammatory response pathways is an important venue associated with host response and pathogenesis of N. GonorrhOEae.
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Novel Treponema pallidum Serologic Tests: A Paradigm Shift in Syphilis Screening for the 21st Century
TL;DR: Clinicians need to understand the science behind these tests to use them properly in syphilis management, and this use of treponemal tests for screening and nontrep onemal serologic tests as confirmatory tests is a reversal of long-held practice.
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Iron piracy: acquisition of transferrin‐bound iron by bacterial pathogens
TL;DR: Sequence comparisons of the genes encoding neisserial transferrin‐binding proteins suggest that they are probably under positive selection for variation and may have resulted from inter‐species genetic exchange.
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The transferrin receptor expressed by gonococcal strain FA1090 is required for the experimental infection of human male volunteers
Cynthia Nau Cornelissen,Meera Kelley,Marcia M. Hobbs,James E. Anderson,J G Cannon,Myron S. Cohen,P. Frederick Sparling +6 more
TL;DR: The transferrin receptor mutant was incapable of initiating urethritis, although the same inoculum size of the wild‐type parent strain, FA1090, causes ure arthritis in >90% of inoculated volunteers.