P
P Imboden
Researcher at University of Bern
Publications - 2
Citations - 1528
P Imboden is an academic researcher from University of Bern. The author has contributed to research in topics: Mycobacterium tuberculosis & rpoB. The author has an hindex of 2, co-authored 2 publications receiving 1479 citations.
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Journal ArticleDOI
Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis
Amalio Telenti,P Imboden,F Marchesi,Lukas Matter,K Schopfer,Thomas Bodmer,Douglas B. Lowrie,M.J Colston,Stewart T. Cole +8 more
TL;DR: Substitution of a limited number of highly conserved aminoacids encoded by the rpoB gene appears to be the molecular mechanism responsible for "single step" high-level resistance to rifampicin in M tuberculosis, a marker of multidrug-resistant tuberculosis.
Journal ArticleDOI
Direct, automated detection of rifampin-resistant Mycobacterium tuberculosis by polymerase chain reaction and single-strand conformation polymorphism analysis
TL;DR: Experience using two different PCR-SSCP formats for the evaluation of BACTEC cultures and sputum is presented here and could result in rapid detection of rifampin resistance in M. tuberculosis, a marker of multidrug-resistant tuberculosis.