Microvoltammetric techniques and sensors for monitoring neurochemical dynamics in vivo. A review

In vivo voltammetry—Present electrodes and methods

Uric acid is reduced in the substantia nigra in Parkinson's disease : effect on dopamine oxidation

Unilateral ligation of the left common carotid artery in anesthetized Mongolian gerbils resulted in a steep rise in extracellular dopamine in the ipsilateral striatum in 9 out of 19 animals. Extracellular dopamine was measured by cerebral dialysis in vivo and reached a peak of 0.19 mM at 40 min. At the same time, the level of homovanillic acid fell, whereas the levels of ascorbate and 3,4-dihydroxyphenylacetic acid remained relatively constant. In a separate group of animals studied with a combined dialysis/electrochemistry probe, a rise in the in vivo chronoamperometric signal in three out of six animals correlated with a rise in extracellular dopamine. The number of animals responding in these experiments (roughly 50%) corresponds to the frequency of incompetent Circle of Willis, as well as literature reports of the frequency of signs of stroke in unanesthetized gerbils. These results show a remarkable accumulation of dopamine in extracellular fluid in response to cerebral ischemia. Released dopamine appears to be responsible for the elevated in vivo electrochemical signal previously reported.

Increase in extracellular dopamine in the striatum during cerebral ischemia: a study utilizing cerebral microdialysis.

Revue bibliographique de 1983 a 1985 classee suivant: livres, transfert de masse, detecteurs, cinetique, effets de surface, electrodes modifiees chimiquement, voltammetrie analytique, caracterisation des systemes redox, bioelectrochimie, spectroelectrochimie, appareillage

P.J. Knott

Papers

In vivo voltammetric evidence of production of uric acid by rat caudate