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P. Lestage

Researcher at French Institute of Health and Medical Research

Publications -  12
Citations -  356

P. Lestage is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Hypothalamus & Volume of distribution. The author has an hindex of 9, co-authored 12 publications receiving 351 citations.

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Plasma, Cerebrospinal Fluid, and Brain Distribution of 14C‐Melatonin in Rat: A Biochemical and Autoradiographic Study

TL;DR: Chromatographic analysis indicated that the radioactivity from biological samples taken at various times following the injection of label was mainly associated with 14C‐MT, which was found in cortex, thalamic nuclei, medial geniculate nucleus, anterior pretectal area, paraventricular nucleus of the hypothalamus, choroid plexuses, and bulb‐pons.
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New quinolinic derivatives as centrally active antioxidants.

TL;DR: A series of new 1,2-dihydro and1,2,3,4-tetrahydroquinolines, synthesized from the corresponding propargylaniline intermediates, have been developed as antioxidants for the potential treatment of pathologies implicating central oxidative stress.
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An in vivo kinetic model with L-[35S]methionine for the determination of local cerebral rates for methionine incorporation into protein in the rat.

TL;DR: In the freely moving rat, the values of methionine incorporation into cerebral protein in the gray matter vary widely from structure to structure, with the highest values in structures related to neurosecretory functions, e.g., supraoptic and para ventricular nuclei.
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A chronic arterial and venous cannulation method for freely moving rats

TL;DR: It is concluded that a prolonged postoperative period and maintaining of the animals in metabolic cages are necessary conditions to obtain a minimal state of stress with this technique.
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Novel 2-Alkylamino-1,4-benzoxazine Derivatives as Potent Neuroprotective Agents: Structure-Activity Relationship Studies

TL;DR: 3,3-diphenyl-substituted-1,4-benzoxazine derivative 3l was identified as the optimal candidate, owing to its potent neuroprotective activity, without the manifestation of intrinsic cytotoxicity, and proved to be effective in an animal model of excitotoxic lesions in newborn mice.