P
P. Manikandan
Researcher at Annamalai University
Publications - 13
Citations - 1024
P. Manikandan is an academic researcher from Annamalai University. The author has contributed to research in topics: Apoptosis & Azadirachta. The author has an hindex of 12, co-authored 13 publications receiving 751 citations. Previous affiliations of P. Manikandan include Auburn University & University of Miami.
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Journal ArticleDOI
Cytochrome P450 Structure, Function and Clinical Significance: A Review
P. Manikandan,Siddavaram Nagini +1 more
TL;DR: This review is a comprehensive compilation of cytochrome P450 structure, function, pharmacogenetics, pharmacoepigenetics and clinical significance that may be used by clinicians to determine therapeutic strategy, and treatment doses for drugs that are metabolized by CYP gene products.
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The neem limonoids azadirachtin and nimbolide inhibit hamster cheek pouch carcinogenesis by modulating xenobiotic-metabolizing enzymes, DNA damage, antioxidants, invasion and angiogenesis.
TL;DR: On a comparative basis, nimbolide was found to be a more potent antioxidant and chemopreventive agent and offers promise as a candidate agent in multitargeted prevention and treatment of cancer.
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The flavonoid quercetin modulates the hallmark capabilities of hamster buccal pouch tumors.
Ramamurthi Vidya Priyadarsini,Govindarajah Vinothini,Ramalingam Senthil Murugan,P. Manikandan,Siddavaram Nagini +4 more
TL;DR: A positive correlation between the inhibition of HDAC-1 and DNMT1 by quercetin and its anticancer properties is found and offers promise as an ideal candidate for multitargeted cancer prevention and therapy.
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Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG.
P. Manikandan,Ramalingam Senthil Murugan,Ramamurthi Vidya Priyadarsini,Govindarajah Vinothini,Siddavaram Nagini +4 more
TL;DR: Phytochemicals such as eugenol that are capable of manipulating the equilibrium between pro- and anti-apoptotic proteins as well as the delicate balance between stimulators and inhibitors of invasion and angiogenesis are attractive candidates for preventing tumour progression.
Journal ArticleDOI
Eugenol inhibits cell proliferation via NF-κB suppression in a rat model of gastric carcinogenesis induced by MNNG
TL;DR: Administration of eugenol significantly reduced the incidence of MNNG-induced gastric tumours by suppressing NF-κB activation and modulating the expression of NF-kkB target genes that regulate cell proliferation and cell survival.