Showing papers in "Life Sciences in 2010"

TL;DR: When utilized carefully, stable isotope geochemistry provides some advantages over conventional methods, and provides an additional device for the ecologist.

TL;DR: The goal of this review is to summarize current developments in the application of stress genes and their products 'Hsps' in toxicology with a brief discussion of the caveats.

TL;DR: A detailed overview of various behavioral paradigms used to assess spatial memory including the T-maze, radial maze, Morris water maze, Barnes maze and others is presented, and the molecular basis of memory in hippocampus called as 'long-term potentiation'.

TL;DR: ABCG2 is a member of the ATP binding cassette (ABC) transporters, which can pump a wide variety of endogenous and exogenous compounds out of cells and has potential applications in stem cell and tumor therapy.

TL;DR: Major in vitro and in vivo findings are summarized showing that quercetin is a MDR modulator and thus a potential chemosensitizer and future prospects of modulating MDR in the clinic are contemplated.

TL;DR: The results suggest that Nrf2/HO-1 signaling pathway may be the primary target for prevention of cisplatin-induced nephrotoxicity by EGCG, and that reduces it inflammation by inhibiting NF-kappaB.

TL;DR: This paper reviewed the biological effects of green tea polyphenol in an attempt to understand its pivotal molecular targets that directly affect the inflammation and joint destruction process for prevention and/or for the development of new therapeutics for arthritis in humans.

TL;DR: An overview of the pro- and anti-inflammatory functions of PECAM-1 is provided with special attention paid to mechanistic insights that have thus far been revealed in the literature in hopes of gaining a clearer picture of how these opposing functions might be integrated in a temporal and spatial manner on the whole organism level.

TL;DR: These studies can provide novel insights into alterations in Ca(2+) wave patterns in carcinogenesis and lead to the development of newer technologies based on Ca( 2+) waves for the diagnosis and therapy of cancer.

TL;DR: Efforts to develop bifunctional peptides containing a micro opioid agonist and a cholecystokinin antagonist or an NK1 receptor antagonist as analgesics expected to produce less tolerance and dependence are reviewed.

TL;DR: This pharmacological profile suggests that orally administered linaclotide may be capable of improving the abdominal symptoms and bowel habits of patients suffering from IBS-C and chronic constipation.

TL;DR: The results indicate that pretreatment with curcumin ameliorates seizures, oxidative stress and cognitive impairment in PTZ induced kindling in rats, and suggest the potential of cur cumin as an adjuvant in epilepsy both to prevent seizures as well as to protect against seizure induced memory impairment.

TL;DR: The combination of cathepsin L inhibition with conventional chemotherapy seems to be more promising and has yielded more consistent results, and future research should be focused on the mechanisms and effects of this combination therapy.

TL;DR: Alcoholism treatment should take sex dimorphism into consideration and a better understanding of the mechanism of action of alcohol in both men and women is needed.

TL;DR: It is found that BPA induced ER stress-associated apoptosis in non-parenchymal hepatocytes, which is due to ROS production and is independent of estrogen receptors.

TL;DR: Results show that Endurance exercise can cause oxidative and mitochondrial stress in liver and that nutrient treatment can either ameliorate or enhance this effect, suggesting that endurance exercise-induced oxidative and mitochondria stress may be either damaging by causing injury or beneficial by activating defense systems.

TL;DR: Findings are a strong indication that fucoidan might inhibit adipogenesis in 3T3-L1 preadipocytes, due to inhibition of the MAPK signaling pathway that involves adipogenic transcription factors.

TL;DR: While this review focuses on cardiac injury and responses of the left ventricle (LV), the mechanisms reviewed here have pathways in common with other wound healing models.

TL;DR: The results showed that the role of quercetin and TRAIL combination therapy may provide a novel strategy for treating prostate cancer by overcoming critical mechanisms of apoptosis resistance.

TL;DR: The data indicate that the anti-inflammatory action of quercetin may be attributable to its raft disrupting and anti-oxidant effects, which work in synergy to down-regulate iNOS expression and NO production.

TL;DR: The functionality of miR-494 in anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide-transformed human bronchial epithelial cell 16HBE to reveal its potential target coding-gene may be a useful target for gene therapy.

TL;DR: It is posits that fatty acid amide hydrolase (FAAH) inhibition has therapeutic potential against neuropathological states including traumatic brain injury; Alzheimer's, Huntington's, and Parkinson's diseases; and stroke.

TL;DR: The results demonstrate that the anti-amnesic effect of neferine may be mediated via antioxidant and anti-inflammatory capacities, as well as inhibition of ChEs and BACE1.

TL;DR: These findings suggest a novel therapy for cancer-induced bone pain, bone loss and bone fracture while lacking many unwanted side effects seen with current treatments for bone cancer pain.

TL;DR: In the presence of oxidative stress, the liver exhibits changes in the carbohydrate and lipid metabolic pathways that would decrease reactive oxygen species production and their deleterious effect, thus inducing little impact on specific antioxidant mechanisms.

TL;DR: Phytochemicals such as eugenol that are capable of manipulating the equilibrium between pro- and anti-apoptotic proteins as well as the delicate balance between stimulators and inhibitors of invasion and angiogenesis are attractive candidates for preventing tumour progression.

TL;DR: It is revealed that the monomeric nature of biological molecules in association with PDGF exerted simultaneous biomimetic and chemotactic effects and promoted wound healing.

TL;DR: It is demonstrated that repetitive hypoxic preconditioning promotes HIF-1alpha-dependent HSP70 signaling to reduce renal ischemia/reperfusion injury and significantly decreased all ischemIA/rePerfusion-enhanced parameters.

TL;DR: The potential utility of DNA methylation of these genes in serum as a promising biomarker and can serve as a surrogate for tumorDNA methylation for diagnosis and prognosis of breast cancer are underscored.

TL;DR: It is demonstrated that the up-regulated expressions of IL-8 or PGE(2) in Streptococci or PAMP-stimulated HDPF were inhibited by catechins, (-)-epicatechin gallate (ECG) and (--epigallocatechin Gallate (EGCG) and the phosphorylation of these signal transduction molecules was suppressed by ctchins.