Advances in the chemistry of dipyrrins and their complexes.

The phototoxic effect (“photodynamic action”) of administered porphyrin in mammals appears to have been first observed by Hausmann (1) in mice and by Meyer-Betz (2) in man. The effect was known in certain porphyrias long before this, but the cause was not known. The localisation of administered porphyrins in tumour tissue was recognised (3) in the 1940s, and this behaviour was explored further in the 1950s in work that led to the development of the HPD preparation (4,5). It was not until 1972 that these two ideas concerning the biological activity of porphyrins (that is, photode-gradation of tissue and localisation in tumours) came together successfully, when Diamond and his colleagues (6) demonstrated that a porphyrin could be used to photosen-sitise the preferential degradation of tumour implants in the rat. In 1975 this result was confirmed and extended by Berenbaum and his colleagues (7), and by Dougherty and his colleagues (8).

HPD - a study of its components and their properties.

Chloroplast biogenesis. Identification of chlorophyllide a (E458f674) as a divinyl chlorophyllide a.

Synthesis of type III isomers of diacetyldeutero-, hemato-, and protoporphyrins with the use of Knorr's pyrrole

The Total Synthesis of Pyrrole Pigments 1973–1980

A range of isomeric diacetyldeuteroporphyrins has been synthesized by the oxidative cyclization of appropriately substituted bilenes-b, and the electronic and n.m.r. spectra of these porphyrins have been studied. As a result it has been shown that the relative position of the two acetyl groups influences the absorption pattern of the visible spectrum more precisely than was previously appreciated. In consequence, it is possible to recognize the 1,4, 2,3 and 2,4 relative distribution of the acetyl groups by an examination of the electronic spectrum. In addition, it is clear that the acetyl groups present in this series of porphyrins affect the chemical shift of all the methine protons and not only the one which is directly adjacent to the carbonyl function.

The chemistry of pyrrolic compounds. XLII. The synthesis of some diacetyldeuteroporphyrins as intermediates in the preparation of the isomeric protoporphyrins: a comparative spectroscopic study of the diacetyldeuteroporphyrins

The chemistry of pyrrolic compounds. xlii. the synthesis of some diacetyldeuteroporphyrins as intermediates in the preparation of the isomeric protoporphyrins: a comparative spectroscopic study of the diacetyldeuteroporphyrins

P. S. Clezy

Papers

The chemistry of pyrrolic compounds. XLII. The synthesis of some diacetyldeuteroporphyrins as intermediates in the preparation of the isomeric protoporphyrins: a comparative spectroscopic study of the diacetyldeuteroporphyrins

The chemistry of pyrrolic compounds. xlii. the synthesis of some diacetyldeuteroporphyrins as intermediates in the preparation of the isomeric protoporphyrins: a comparative spectroscopic study of the diacetyldeuteroporphyrins