P
Pablo Astudillo
Researcher at Autonomous University of Chile
Publications - 20
Citations - 644
Pablo Astudillo is an academic researcher from Autonomous University of Chile. The author has contributed to research in topics: Wnt signaling pathway & Cellular differentiation. The author has an hindex of 10, co-authored 20 publications receiving 512 citations. Previous affiliations of Pablo Astudillo include University of Chile & Pontifical Catholic University of Chile.
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Increased adipogenesis of osteoporotic human-mesenchymal stem cells (MSCs) characterizes by impaired leptin action.
TL;DR: Results obtained during adipogenesis of osteoporotic cells suggest that this process is abnormal not only because of increased adipocyte number, but because of impaired leptin cells response.
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Involvement of Adipogenic Potential of Human Bone Marrow Mesenchymal Stem Cells (MSCs) in Osteoporosis
TL;DR: Experimental evidence is analyzed which describes differences in the osteogenic/adipogenic potentials of human bone marrow MSCs obtained from control and osteoporotic postmenopausal women, suggesting that inadequate leptin activity contributes to excessive lipid accumulation in bone marrow.
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Mechanosensitivity of integrin adhesion complexes: role of the consensus adhesome.
TL;DR: The function of the consensus adhesome, an assembly of core IAC proteins that emerged from a meta-analysis of multiple proteomic datasets, is reviewed in the context of mechanosensing.
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Concentration of adipogenic and proinflammatory cytokines in the bone marrow supernatant fluid of osteoporotic women.
Ana María Pino,Susana Ríos,Pablo Astudillo,Mireya Fernández,Paula Figueroa,Germán Seitz,J. Pablo Rodríguez +6 more
TL;DR: The cytokines' concentration in BMSF showed differently among nonosteoporotic and osteoporosis women; this last group was characterized by higher content of proinflammatory and adipogenic cytokines, suggesting that insufficient leptin action may distinguish the osteop orotic bone marrow.
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Aromatase activity of human mesenchymal stem cells is stimulated by early differentiation, vitamin D and leptin
Ana María Pino,Juan Manuel Rodríguez,Susana Ríos,Pablo Astudillo,Laura Leiva,Germán Seitz,Mireya Fernández,J. Pablo Rodríguez +7 more
TL;DR: It is shown that favourable aromatase substrates concentration restrained MSCs adipogenesis but improved osteogenesis, and it could be inferred that a high and early increase of local oestrogen concentration in hMSCs affects their commitment either restraining AD or facilitating OS differentiation, or both.