P
Paige Garrison
Researcher at University at Buffalo
Publications - 4
Citations - 17
Paige Garrison is an academic researcher from University at Buffalo. The author has contributed to research in topics: Trypanosoma brucei & Cathepsin L. The author has an hindex of 2, co-authored 3 publications receiving 4 citations.
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Journal ArticleDOI
p97 Inhibitor CB-5083 Blocks ERAD in Trypanosoma brucei.
Paige Garrison,James D. Bangs +1 more
TL;DR: An orally bioavailable p97 inhibitor is evaluated, CB-5083, for use in T. brucei and it is suggested that CB- 5083 blocks ERAD upstream of the proteasome, as expected for inhibition of the trypanosomal p97 orthologue TbVCP.
Journal ArticleDOI
Turnover of Variant Surface Glycoprotein in Trypanosoma brucei Is a Bimodal Process.
Paige Garrison,Umaer Khan,Michael J. Cipriano,Peter J. Bush,Jacquelyn R McDonald,Aakash Sur,Aakash Sur,Peter J. Myler,Terry K. Smith,Stephen L. Hajduk,James D. Bangs +10 more
TL;DR: In this paper, the authors used United States Public Health Service grant R01 AI035739 and funds from the Jacobs School of Medicine and Biomedical Sciences to J.B. et al. and from United States public health Service grant 1S10OD021719-01A1 to the University of Georgia, which purchased the ImageStreamX Mk II.
Journal ArticleDOI
Turnover of Variant Surface Glycoprotein in Trypanosoma brucei Is Not Altered in Response to Specific Silencing
TL;DR: In this paper , the authors investigated whether African trypanosomes under VSG silencing also reduce the rate of VSG turnover to further conserve coat density, and they found that the surface morphology of silenced cells was altered from a typically rugose topology to a smoother profile, consistent with reduced overall membrane trafficking to the cell surface.
Journal ArticleDOI
The role of glycosylphosphatidylinositol phospholipase C in membrane trafficking in Trypanosoma brucei.
TL;DR: In this paper, the effect of GPI-PLC deficiency on membrane trafficking and phosphoinositide metabolism in African trypanosomes was investigated using a null cell line.