Institution
Seattle Children's Research Institute
Healthcare•
About: Seattle Children's Research Institute is a based out in . It is known for research contribution in the topics: Population & Poison control. The organization has 2305 authors who have published 3907 publications receiving 106131 citations.
Topics: Population, Poison control, Medicine, Health care, Immune system
Papers published on a yearly basis
Papers
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TL;DR: The mRNA-1273 vaccine induced anti-SARS-CoV-2 immune responses in all participants, and no trial-limiting safety concerns were identified, which support further development of this vaccine.
Abstract: Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and spread globally, prompting an international effort to accelerate development of a vacci...
2,556 citations
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TL;DR: Experimental and analytical approaches relating to exome sequencing have established a rich framework for discovering the genes underlying unsolved Mendelian disorders and set the stage for applying exome and whole-genome sequencing to facilitate clinical diagnosis and personalized disease-risk profiling.
Abstract: Exome sequencing — the targeted sequencing of the subset of the human genome that is protein coding — is a powerful and cost-effective new tool for dissecting the genetic basis of diseases and traits that have proved to be intractable to conventional gene-discovery strategies. Over the past 2 years, experimental and analytical approaches relating to exome sequencing have established a rich framework for discovering the genes underlying unsolved Mendelian disorders. Additionally, exome sequencing is being adapted to explore the extent to which rare alleles explain the heritability of complex diseases and health- related traits. These advances also set the stage for applying exome and whole-genome sequencing to facilitate clinical diagnosis and personalized disease-risk profiling.
1,672 citations
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TL;DR: It is demonstrated that human CD19(+)CD24(hi)CD38(HI) B cells possessed regulatory capacity, and altered cellular function within this compartment may impact effector immune responses in SLE and other autoimmune disorders.
1,362 citations
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TL;DR: Recurrent multifocal glioblastoma patients received chimeric antigen receptor (CAR)-engineered T cells targeting the tumor-associated antigen interleukin-13 receptor alpha 2 (IL13Rα2) and regression of all intracranial and spinal tumors was observed, along with corresponding increases in levels of cytokines and immune cells in the cerebrospinal fluid.
Abstract: A patient with recurrent multifocal glioblastoma received chimeric antigen receptor (CAR)-engineered T cells targeting the tumor-associated antigen interleukin-13 receptor alpha 2 (IL13Rα2). Multiple infusions of CAR T cells were administered over 220 days through two intracranial delivery routes - infusions into the resected tumor cavity followed by infusions into the ventricular system. Intracranial infusions of IL13Rα2-targeted CAR T cells were not associated with any toxic effects of grade 3 or higher. After CAR T-cell treatment, regression of all intracranial and spinal tumors was observed, along with corresponding increases in levels of cytokines and immune cells in the cerebrospinal fluid. This clinical response continued for 7.5 months after the initiation of CAR T-cell therapy. (Funded by Gateway for Cancer Research and others; ClinicalTrials.gov number, NCT02208362 .).
1,221 citations
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TL;DR: The authors profiled almost 50,000 single cells from an individual Caenorhabditis elegans larval stage and were able to identify and recover information from different, even rare, cell types and develop combinatorial indexing strategies to profile the transcriptomes of single cells or nuclei.
Abstract: To resolve cellular heterogeneity, we developed a combinatorial indexing strategy to profile the transcriptomes of single cells or nuclei, termed sci-RNA-seq (single-cell combinatorial indexing RNA sequencing). We applied sci-RNA-seq to profile nearly 50,000 cells from the nematode Caenorhabditis elegans at the L2 larval stage, which provided >50-fold “shotgun” cellular coverage of its somatic cell composition. From these data, we defined consensus expression profiles for 27 cell types and recovered rare neuronal cell types corresponding to as few as one or two cells in the L2 worm. We integrated these profiles with whole-animal chromatin immunoprecipitation sequencing data to deconvolve the cell type–specific effects of transcription factors. The data generated by sci-RNA-seq constitute a powerful resource for nematode biology and foreshadow similar atlases for other organisms.
1,028 citations
Authors
Showing all 2326 results
Name | H-index | Papers | Citations |
---|---|---|---|
David Baker | 173 | 1226 | 109377 |
Jay Shendure | 135 | 466 | 76953 |
Frederick P. Rivara | 118 | 940 | 86352 |
Patrick J. McGrath | 107 | 681 | 51940 |
Adam Drewnowski | 106 | 486 | 41107 |
William B. Dobyns | 105 | 430 | 38956 |
Hans D. Ochs | 102 | 419 | 39881 |
Alan Aderem | 99 | 246 | 46682 |
Michael K. Skinner | 93 | 333 | 31835 |
Deborah A. Nickerson | 88 | 400 | 38477 |
Michael J. Bamshad | 86 | 334 | 35118 |
Brian E. Saelens | 85 | 281 | 35223 |
Gary K. Owens | 81 | 207 | 20607 |
Janet A. Englund | 80 | 360 | 20298 |
Dimitri A. Christakis | 79 | 284 | 20590 |