P
Pan Kong
Researcher at University of Southern California
Publications - 3
Citations - 997
Pan Kong is an academic researcher from University of Southern California. The author has contributed to research in topics: Neurodegeneration & GLUT1. The author has an hindex of 3, co-authored 3 publications receiving 721 citations.
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Journal ArticleDOI
GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration
Ethan A. Winkler,Ethan A. Winkler,Yoichiro Nishida,Yoichiro Nishida,Abhay P. Sagare,Sanket V Rege,Robert D. Bell,David H. Perlmutter,Jesse D. Sengillo,Jesse D. Sengillo,Sara E. Hillman,Pan Kong,Amy R. Nelson,John S. Sullivan,Zhen Zhao,Herbert J. Meiselman,Rosalinda B. Wenby,Jamie Soto,Jamie Soto,E. Dale Abel,E. Dale Abel,Jacob Makshanoff,Edward Zuniga,Darryl C. De Vivo,Berislav V. Zlokovic +24 more
TL;DR: Reduced BBB GLUT1 expression worsens Alzheimer's disease cerebrovascular degeneration, neuropathology and cognitive function, suggesting thatGLUT1 may represent a therapeutic target for Alzheimer's Disease vasculo-neuronal dysfunction and degeneration.
Journal ArticleDOI
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
Zhen Zhao,Abhay P. Sagare,Qingyi Ma,Matthew R. Halliday,Pan Kong,Kassandra Kisler,Ethan A. Winkler,Anita Ramanathan,Takahisa Kanekiyo,Guojun Bu,Nelly Chuqui Owens,Sanket V Rege,Gabriel Si,Ashim Ahuja,Donghui Zhu,Carol A. Miller,Julie A. Schneider,Manami Maeda,Takahiro Maeda,Takahiro Maeda,Tohru Sugawara,Justin K. Ichida,Berislav V. Zlokovic +22 more
TL;DR: PICALM regulated PICALM/clathrin-dependent internalization of Aβ bound to the low density lipoprotein receptor related protein-1, a key Aβ clearance receptor, and guided Aβ trafficking to Rab5 and Rab11, leading to Aβ endothelial transcytosis and clearance.
Journal ArticleDOI
Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss.
Angeliki M. Nikolakopoulou,Axel Montagne,Kassandra Kisler,Zhonghua Dai,Yaoming Wang,Mikko T Huuskonen,Abhay P. Sagare,Divna Lazic,Divna Lazic,Melanie D. Sweeney,Pan Kong,Min Wang,Nelly Chuqui Owens,Erica J. Lawson,Xiaochun Xie,Zhen Zhao,Berislav V. Zlokovic +16 more
TL;DR: Using pericyte-specific Cre and ablation mouse lines, the authors show that loss of brain pericytes leads to circulatory failure and reduced pleiotrophin causing rapid neuron loss, demonstrating a rapid neurodegeneration cascade.