P
Paolo Ascenzi
Researcher at Roma Tre University
Publications - 552
Citations - 20593
Paolo Ascenzi is an academic researcher from Roma Tre University. The author has contributed to research in topics: Heme & Human serum albumin. The author has an hindex of 64, co-authored 534 publications receiving 18457 citations. Previous affiliations of Paolo Ascenzi include Accademia Nazionale dei Lincei & University of Genoa.
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Journal ArticleDOI
Human serum albumin: from bench to bedside.
TL;DR: HSA is a valuable biomarker of many diseases, including cancer, rheumatoid arthritis, ischemia, post-menopausal obesity, severe acute graft-versus-host disease, and diseases that need monitoring of the glycemic control.
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The extraordinary ligand binding properties of human serum albumin
Mauro Fasano,Stephen Curry,Enzo Terreno,Monica Galliano,Gabriella Fanali,Pasquale Narciso,Stefania Notari,Paolo Ascenzi +7 more
TL;DR: The globular domain structural organization of monomeric HSA is at the root of its allosteric properties which are reminiscent of those of multimeric proteins.
Journal ArticleDOI
Estrogen signaling multiple pathways to impact gene transcription.
TL;DR: This review will focus on the recent knowledge about the mechanism by which ERs regulate the expression of target genes and the emerging field of integration of membrane and nuclear receptor signaling, giving examples of the ways by which the genomic and non-genomic actions of ERs on target genes converge.
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Structure–function relationship of estrogen receptor α and β: Impact on human health
TL;DR: Understanding the structural basis and the molecular mechanisms by which ER transduce E2 signals in target cells will allow to create new pharmacologic therapies aimed at the treatment of a variety of human diseases affecting the cardiovascular system, the reproductive system, and the skeletal system.
Journal ArticleDOI
Palmitoylation-dependent estrogen receptor α membrane localization: Regulation by 17β-estradiol
Filippo Acconcia,Paolo Ascenzi,Alessio Bocedi,Enzo Spisni,Vittorio Tomasi,Anna Trentalance,Paolo Visca,Maria Marino +7 more
TL;DR: In this article, the role of palmitoylation and the impact of E2 stimulation on ERα membrane localization was investigated in cancer cell lines expressing transfected or endogenous human ERα (HeLa and HepG2, respectively).