P
Paolo Brunetti
Researcher at University of Perugia
Publications - 198
Citations - 10690
Paolo Brunetti is an academic researcher from University of Perugia. The author has contributed to research in topics: Insulin & Diabetes mellitus. The author has an hindex of 56, co-authored 198 publications receiving 10376 citations.
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Journal ArticleDOI
Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.
M. Lepore,S. Pampanelli,Carmine G. Fanelli,Francesca Porcellati,L Bartocci,A. Di Vincenzo,C Cordoni,E Costa,Paolo Brunetti,Geremia B. Bolli +9 more
TL;DR: Glargine is a peakless insulin, it lasts nearly 24 h, it has lower intersubject variability than NPH and ultralente, and it closely mimics CSII, the gold standard of basal insulin replacement.
Journal ArticleDOI
Relation Between Serum Uric Acid and Risk of Cardiovascular Disease in Essential Hypertension: The PIUMA Study
Paolo Verdecchia,Giuseppe Schillaci,Gianpaolo Reboldi,Fausto Santeusanio,Carlo Porcellati,Paolo Brunetti +5 more
TL;DR: In untreated subjects with essential hypertension, raised uric acid is a powerful risk marker for subsequent cardiovascular disease and all-cause mortality.
Journal ArticleDOI
Abnormal Glucose Counterregulation in Insulin-dependent Diabetes Mellitus: Interaction of Anti-Insulin Antibodies and Impaired Glucagon and Epinephrine Secretion
Geremia B. Bolli,De Feo P,P. Compagnucci,Cartechini Mg,Gabriella Angeletti,Fausto Santeusanio,Paolo Brunetti,John E. Gerich +7 more
TL;DR: It is concluded that impaired A-cell secretion is the predominant mechanism for the delayed glucose recovery after hypoglycemia in diabetic patients without insulin antibodies and normal epinephrine responses, which appears to be acquired defects that develop subsequent to B-cell failure.
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Meticulous Prevention of Hypoglycemia Normalizes the Glycemic Thresholds and Magnitude of Most of Neuroendocrine Responses to, Symptoms of, and Cognitive Function During Hypoglycemia in Intensively Treated Patients With Short-Term IDDM
Carmine G. Fanelli,Lucilla Epifano,Aanna Maria Rambotti,S. Pampanelli,Antonio Di Vincenzo,Francesco Modarelli,M. Lepore,Bruno Annibale,M. Ciofetta,P. Bottini,Francesca Porcellati,Scionti L,Fausto Santeusanio,Paolo Brunetti,B Bolli Geremia +14 more
TL;DR: It is concluded that hypoglycemia unawareness in IDDM is largely reversible and that intensive insulin therapy and a program of intensive education may substantially prevent hypoglyCEmia and at the same time maintain the glycemic targets of intensive insulin Therapy, at least in patients with IDDM of short duration.
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Microencapsulated Pancreatic Islet Allografts Into Nonimmunosuppressed Patients With Type 1 Diabetes First two cases
Riccardo Calafiore,Giuseppe Basta,Giovanni Luca,Angelo Lemmi,M. Pia Montanucci,G. Calabrese,Leda Racanicchi,Francesca Mancuso,Paolo Brunetti +8 more
TL;DR: A phase 1 pilot clinical trial of microencapsulated TX into 10 nonimmunosuppressed patients with type 1 diabetes, under permission and surveillance by the Italian Ministry of Health is initiated.