Paolo Cotzia

TL;DR: NTRK fusion-positive uterine spindle cell sarcomas constitute a novel tumor type with features of fibrosarcoma; patients with these tumors may benefit from Trk inhibition.

TL;DR: The findings suggest a higher shedding risk in less symptomatic patients, an important consideration for containment strategies, and identify a novel association between VL and history of cancer.

TL;DR: Findings together with the recurrent gene fusions in RAF1, BRAF, and NTRK1/2 kinases suggest a distinct molecular tumor subtype with consistent S100 and CD34 immunoreactivity.

TL;DR: The results expand the spectrum of genetic alterations in PHE with a novel gene fusion identified in half of the cases, and it is speculated that some of the novel targeted therapies that have shown promise in SERPINE1-FOSB-positive PHE might also be beneficial in this molecular subset.

TL;DR: The tumor microenvironment frequently displays abnormal cellular metabolism, which contributes to aggressive behavior, and metformin inhibits mitochondrial oxidative phosphorylation, altering metabolism.