Showing papers by "Paolo Pani published in 2000"
TL;DR: It is suggested that sunlight, an established risk factor for human skin carcinogenesis, is able to induce rare altered cells resistant to toxicity and to favour their clonal expansion via toxic effects exerted on normal keratinocytes through imposition of a constrained growth environment in the target organ.
Abstract: Phenotypic resistance, acquired early in carcinogenesis, has an established role in the pathogenesis of cancer in well-characterised experimental systems, and possibly also has a role in the origin of human cancer. It has been suggested that sunlight, an established risk factor for human skin carcinogenesis, is able to induce rare altered cells resistant to toxicity and to favour their clonal expansion via toxic effects exerted on normal keratinocytes. Other major risk factors for human neoplasia, including smoking and ageing, may also act partly through imposition of a constrained growth environment in the target organ to favour the emergence of altered resistant cells. Strategies aimed at counteracting this constrained environment could be effective in attenuating the force that sustains clonal expansion of altered cells.
38 citations
TL;DR: In this article, the effect of a stress-associated condition on chemical hepatocarcinogenesis in the rat was examined, and it was shown that exposure to restraint stress early during carcinogenesis enhances the development of chemically-induced hepatocellular carcinoma in rat.
22 citations