Aquatic contamination of diclofenac (DCF), an emergent non-steroidal anti-inflammatory drug (NSAIDs), can result in adverse effects to many ecosystems through biomagnification. Hence, introducing effective remediation techniques to sequester the pharmaceutical wastes is highly fundamental to prevent their accumulation in the environment. Generally, adsorption has been presented as a green and efficient approach. Herein, we report the characterization and application of the novel magnetic nanocomposite (GO@CoFe2O4) derived from cobalt-based ferrite (CoFe2O4) and graphene oxide (GO) for DCF adsorption. For the optimization procedure, the response surface methodology (RSM) was adopted to investigate the impacts of DCF concentration (1.6–18.4 mg/L), DCF dosage (0.08–0.92 g/L), and solution pH (2.6–9.4) to find the optimum conditions for DCF removal, at 10.5 mg/L, 0.74 g/L, and pH 4, respectively. For the adsorption experiments, the kinetic, isotherm, thermodynamic, and intraparticle diffusion models were systematically studied. Moreover, we have elucidated the role of functional groups on the surface of GO@CoFe2O4 in enhancing the adsorption of DCF drug. With good removal efficiency (up to 86.1%), high maximum adsorption capacity (32.4 mg/g), GO@CoFe2O4 can be a potential candidate to eliminate DCF drug from water.

Optimization, equilibrium, adsorption behavior and role of surface functional groups on graphene oxide-based nanocomposite towards diclofenac drug.

3D printing technology as innovative solutions for biomedical applications.

Three-dimensional (3D) bioprinting has become a promising strategy for bone manufacturing, with excellent control over geometry and microarchitectures of the scaffolds. The bioprinting ink for bone and cartilage engineering has thus become the key to developing 3D constructs for bone and cartilage defect repair. Maintaining the balance of cellular viability, drugs or cytokines' function, and mechanical integrity is critical for constructing 3D bone and/or cartilage scaffolds. Photo-crosslinkable hydrogel is one of the most promising materials in tissue engineering; it can respond to light and induce structural or morphological transition. The biocompatibility, easy fabrication, as well as controllable mechanical and degradation properties of photo-crosslinkable hydrogel can meet various requirements of the bone and cartilage scaffolds, which enable it to serve as an effective bio-ink for 3D bioprinting. Here, in this review, we first introduce commonly used photo-crosslinkable hydrogel materials and additives (such as nanomaterials, functional cells, and drugs/cytokine), and then discuss the applications of the 3D bioprinted photo-crosslinkable hydrogel scaffolds for bone and cartilage engineering. Finally, we conclude the review with future perspectives about the development of 3D bioprinting photo-crosslinkable hydrogels in bone and cartilage engineering.

http://ijb.whioce.com/index.php/int-j-bioprinting/article/viewFile/367/pdf

3D Bioprinting Photo-Crosslinkable Hydrogels for Bone and Cartilage Repair

https://doi.org/10.1016/j.bioactmat.2022.01.038

Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design

The triad of nanotechnology, cell signalling, and scaffold implantation for the successful repair of damaged organs: An overview on soft-tissue engineering.

Despite astounding developments in regenerative medicine, efficient cell differentiation has still met some struggles in conventional methods. Since mechanical ques are responsible for the communications between stem cells and their niche, advanced tissue engineering has introduced the novel branch of mechanobiology to manipulate organogenesis. Taking advantage of unique topographical microenvironment and physiochemical features, nanomaterials provide the opportunity to control cellular functions through multidimensional approaches. An overview of mechanobiology science reveals an interface of the disparate scientific disciplines from biology to mechanics. Accordingly, mathematical modeling is instrumental in the explosive progress of this area, assisting experimental studies on myriad levels. This chapter is inspired to generate discussions in mechanobiology from the fundamental conceptions to the cutting-edge developments. Moreover, the role of various biomaterials, magnetic nanoparticles, and conductive segments are examined, besides their relative physio-mechanical computations.

Parinaz Abdollahiyan

Papers

How Physics Can Regulate Stem Cells’ Fate: An Overview on Cellular Interactions with Their Substrate