P
Partha Krishnamurthy
Researcher at University of Kansas
Publications - 37
Citations - 3115
Partha Krishnamurthy is an academic researcher from University of Kansas. The author has contributed to research in topics: ATP-binding cassette transporter & Heme. The author has an hindex of 23, co-authored 37 publications receiving 2680 citations. Previous affiliations of Partha Krishnamurthy include St. Jude Children's Research Hospital.
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Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.
Kuo Du,Anup Ramachandran,James L. Weemhoff,Hemantkumar Chavan,Yuchao Xie,Partha Krishnamurthy,Hartmut Jaeschke +6 more
TL;DR: Pretreatment with metformin protects against APAP hepatotoxicity by attenuating the mitochondrial oxidant stress and subsequent mitochondrial dysfunction, and may be a potential therapeutic option for APAP overdose patients.
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Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice.
Bharat Bhushan,Hemantkumar Chavan,Prachi Borude,Yuchao Xie,Kuo Du,Mitchell R. McGill,Margitta Lebofsky,Hartmut Jaeschke,Partha Krishnamurthy,Udayan Apte +9 more
TL;DR: A new dual role of EGFR is revealed both in initiation of APAP-injury and in stimulation of subsequent compensatory regeneration afterAPAP-overdose, which is completely unknown.
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Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism.
Xing Liu,Yuan-Fu Lu,Xinfu Guan,Bingning Dong,Hemantkumar Chavan,Jin Wang,Yiqing Zhang,Partha Krishnamurthy,Feng Li +8 more
TL;DR: More knowledge is provided of GEF bioactivation and enzymes involved in metabolic pathways, which can be utilized for understanding the mechanism of adverse effects associated with GEF and predicting possible drug-drug interactions.
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Targeting the Enterohepatic Bile Acid Signaling Induces Hepatic Autophagy via a CYP7A1–AKT–mTOR Axis in Mice
Yifeng Wang,Yifeng Ding,Jibiao Li,Hemantkumar Chavan,David J. Matye,Hong-Min Ni,John Y.L. Chiang,Partha Krishnamurthy,Wen-Xing Ding,Tiangang Li +9 more
TL;DR: A novel CYP7A1–AKT–mTOR signaling axis that selectively induces hepatic autophagy, which helps improve hepatocellular integrity and metabolic homeostasis is identified.
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Regulation of energy metabolism during early mammalian development: TEAD4 controls mitochondrial transcription.
Ram Parikshan Kumar,Soma Ray,Pratik Home,Biswarup Saha,Bhaswati Bhattacharya,Heather M. Wilkins,Hemantkumar Chavan,Avishek Ganguly,Jessica Milano-Foster,Arindam Paul,Partha Krishnamurthy,Russell H. Swerdlow,Soumen Paul +12 more
TL;DR: It is shown that conserved transcription factor TEAD4, which is essential for pre-implantation mammalian development, regulates this process by promoting mitochondrial transcription and oxidative energy metabolism in the trophectoderm lineage to ensure mammalian development.