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Patience O. Obi
Researcher at University of Manitoba
Publications - 11
Citations - 456
Patience O. Obi is an academic researcher from University of Manitoba. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 5 publications receiving 75 citations. Previous affiliations of Patience O. Obi include Boston Children's Hospital.
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Journal ArticleDOI
A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option?
TL;DR: It is argued that exosomes isolated via SEC are relatively pure and functional, and that this methodology is reproducible, scalable, inexpensive, and does not require specialized equipment or user expertise.
Posted ContentDOI
A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option?
TL;DR: It is argued that exosomes isolated via SEC are relatively pure and functional, and that this methodology is reproducible, scalable, inexpensive, and does not require specialized equipment or user expertise.
Journal ArticleDOI
Exosomes, autophagy and ER stress pathways in human diseases: Cross-regulation and therapeutic approaches.
Babak Jahangiri,Ali Kian Saei,Patience O. Obi,Narjes Asghari,Shahrokh Lorzadeh,Shirin Hekmatirad,Marveh Rahmati,Fatemeh Velayatipour,Mohammad Hossein Asghari,Ayesha Saleem,Mohammad Amin Moosavi +10 more
TL;DR: In this paper , the authors review the available information on the mechanisms that control autophagy, ER stress and EV pathways, with the view that a better understanding of their crosstalk and balance may improve our knowledge on the pathogenesis and treatment of human diseases, where these pathways are dysregulated.
Journal ArticleDOI
Characterizing Extracellular Vesicles and Particles Derived from Skeletal Muscle Myoblasts and Myotubes and the Effect of Acute Contractile Activity
Benjamin Bydak,T.M. Pierdoná,Samira Seif,Karim Sidhom,Patience O. Obi,Hagar I. Labouta,Joseph W. Gordon,Ayesha Saleem +7 more
TL;DR: The data show that EVs differed in size, distribution, protein yield and expression of subtype markers pre vs. post skeletal muscle–differentiation into myotubes, and there was no effect of acute stimulation on biophysical profile or protein markers in EPs.
Posted ContentDOI
Extracellular vesicles as predictors of individual response to exercise training in youth living with obesity
Taiana M. Pierdoná,Taiana M. Pierdoná,Alexandria Martin,Alexandria Martin,Patience O. Obi,Patience O. Obi,Samira Seif,Samira Seif,Benjamin Bydak,Benjamin Bydak,Ashley L. Eadie,Keith R. Brunt,Jonathan McGavock,Jonathan McGavock,Martin Sénéchal,Ayesha Saleem +15 more
TL;DR: The data suggest that youth with obesity that respond to exercise training produce larger EVs, with lower exosome- and higher microvesicle-specific protein expression, and the individual response to exercise has yet to be fully elucidated.