Showing papers by "Patoomratana Tuchinda published in 2004"
TL;DR: Two new cycloartanes, tubiferolide methyl ester (1) and tubiferaoctanolide (2), together with the known coronalolide (3 ) and coronaloline methyl esters (4 ) have been isolated from leaves and twigs of Gardenia tubifera as discussed by the authors, and a new flavone 5,3′,5′-trihydroxy-7,4′-dimethoxyflavone (5), five known flavones 6-10 and hexacosyl 4′-hydroxytrans-
41 citations
TL;DR: Seven compounds isolated from the leaves and twigs of Gardenia thailandica Tirveng exhibited anti-HIV-1 activities as determined by using the (Delta)(Tat/Rev)MC99 virus and 1A2 cell line system.
Abstract: Thailandiol ( 1), gardenolic acid A ( 2), quadrangularic acid E ( 3) and 3beta-hydroxy-5alpha-cycloart-24(31)-en-28-oic acid ( 4) have been isolated from the leaves and twigs of Gardenia thailandica Tirveng (order: Rubiales; family: Rubiaceae) In addition, 5-hydroxy-7,2',3',4',5',6'-hexamethoxyflavone ( 5), 5,7-dihydroxy-2',3', 4',5',6'-pentamethoxyflavone ( 6), 5-hydroxy-7,2',3',4',5'-pentamethoxyflavone ( 7) and 5,7-dihydroxy-2',3',4',5'-tetramethoxyflavone ( 8) were also isolated from the same source The structures were elucidated by spectroscopic methods Crude extracts and compounds 1 - 4 displayed anti-HIV-1 activities as determined by using the (Delta)(Tat/Rev)MC99 virus and 1A2 cell line system The EC (50) values determined by the syncytium assay ranged from < 78 to 110 microg/mL They also exhibited moderate to high activities in reverse transcriptase (RT) assay; the IC (50) values of compounds 1 - 4, ranged from < 225 to 1568 microg/mL
29 citations
TL;DR: In this paper, the bromine−magnesium exchange reaction of arylthiobromodifluoromethanes with Grignard reagents has been studied.
19 citations
TL;DR: The vicinal dianions derived from chiral succinic acid derivatives, 1,4-bis[(4 R, 5 S )-3, 4-dimethyl-2-oxo-5-phenylimidazolidin-1-yl]butane-1, 4 -dione and 1 4-bis [(4 S, 5 R )]-1 4-dione react with arylmethyl bromides with high diastereo-and regio-selectivity to provide the corresponding chiral α-arylmethylated succ
14 citations
TL;DR: In this paper, Vicinal dianions of diethyl α-aroylsuccinates react with aromatic aldehydes to provide functionalized 2,3-dihydrofurans as the major products together with γ-butyrolactones.
Abstract: Vicinal dianions of diethyl α-aroylsuccinates react with aromatic aldehydes to provide functionalized 2,3-dihydrofurans as the major products together with γ-butyrolactones after treatment of the adducts obtained with a catalytic amount of p-toluenesulfonic acid in refluxing toluene. cis-2,3-Dihydrofurans are used as precursors for the preparation of tetrasubstituted furans and diaxial 2,4-diaryl-3,7-dioxabicyclo[3.3.0]octanes.