Patrick A. Newbury

TL;DR: Comparison of genomic and transcriptomic profiles of different breast cancer cell lines and organoids to data from patient-derived breast cancer metastases reveals substantial genomic differences and suggests that organoids more closely resemble the transcriptome of metastatic breast cancer samples compared to cell lines.

TL;DR: Open Cancer TherApeutic Discovery (OCTAD) as discussed by the authors is a software pipeline for finding drugs that alter gene expression in such a way that they are likely to reverse the expression pattern of the disease.

TL;DR: This work presents OCTAD: an open workplace for virtually screening compounds targeting precise cancer patient groups using gene expression features and releases OCTAD as a web portal and standalone R workflow to allow experimental and computational scientists to easily navigate the tool.

TL;DR: This study demonstrates that transcriptomic features can serve as indicators of severity that could be superior to traditional methods of ascertaining acuity in MODS patients.

TL;DR: This study highlights the significant negative impact of relaxed motorcycle helmet laws leading to an increase in craniomaxillofacial injuries in Michigan and urges state and national legislators to reestablish universal helmet laws.