P
Patrick K. Henthorn
Researcher at Anschutz Medical Campus
Publications - 1
Citations - 11
Patrick K. Henthorn is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: KRAS & MEK inhibitor. The author has an hindex of 1, co-authored 1 publications receiving 11 citations.
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Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts.
Christopher H. Lieu,Peter J. Klauck,Patrick K. Henthorn,John J. Tentler,Aik Choon Tan,Anna Spreafico,Heather M. Selby,Blair C. Britt,Stacey M. Bagby,John J. Arcaroli,Wells A. Messersmith,Todd M. Pitts,S. Gail Eckhardt +12 more
TL;DR: The MEK inhibitor TAK-733 demonstrated robust antitumor activity against CRC cell lines and patient-derived tumor explants, supporting the use of these models in an iterative manner to elucidate resistance mechanisms that can guide rational combination strategies.