Showing papers by "Patrick L. McGeer published in 1985"
TL;DR: The pharmacohistochemical neuronal staining method for gamma-aminobutyric transaminase (GABA-T) combined with retrograde horseradish peroxidase (HRP) staining was used to define more precisely the descending striatonigral and pallidonigral pathways.
63 citations
TL;DR: The pharmacohistochemical method used to identify the distribution in rat brain of γ‐aminobutyric acid transaminase (GABA‐T)‐intensive neurons has been applied to the rat pons and medulla and provides further support for the hypothesis that GABA neurons are far more GABA‐T‐intensive than other neurons in the central nervous system.
Abstract: The pharmacohistochemical method previously used to identify the distribution in rat brain of gamma-aminobutyric acid transaminase (GABA-T)-intensive neurons has been applied to the rat pons and medulla. The method involves systemic administration of the irreversible GABA-T inhibitor Gabaculine and the detection, 12 to 15 hours after the injection of the newly synthesized GABA-T by histochemical means. GABA-T-intensive neurons were found to be rich in the following hindbrain structures: inferior colliculus, nuclei of the raphe system, nuclei parabrachialis dorsalis and ventralis, nucleus cuneiformis, nucleus vestibularis medialis, nucleus tractus spinalis nervi trigemini, nucleus vagus, nucleus cochlearis, nucleus reticularis lateralis, nucleus ambiguus, nucleus cuneatus lateralis, inferior olive, and reticular formation of the pons and medulla. Neurons of the deep cerebellar nuclei and the rostral portion of the lateral vestibular nucleus were negative for GABA-T but were surrounded by granular staining indicative of impinging GABA-T-rich nerve endings. These results provide further support for the hypothesis that GABA neurons are far more GABA-T-intensive than other neurons in the central nervous system.
58 citations
TL;DR: The regional distributions of the enzymes in the infants were generally as expected from adult control data except for that of ChAT in one of the two cases of crib death; the AChE activities seemed extraordinarily high, especially in the case of Down's syndrome.
37 citations
TL;DR: Presumptive cholinergic and GABAergic neurons are damaged to a similar extent, but somatostatin neurons are more sensitive to the neurotoxic effect of kainic acid and are more severely affected.
37 citations