P
Patrick Nugent
Researcher at University of Washington
Publications - 2
Citations - 211
Patrick Nugent is an academic researcher from University of Washington. The author has contributed to research in topics: Gene & Nucleotide excision repair. The author has an hindex of 2, co-authored 2 publications receiving 151 citations.
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Journal ArticleDOI
Inhibiting the Evolution of Antibiotic Resistance.
Mark N. Ragheb,Maureen K. Thomason,Chris Hsu,Patrick Nugent,John Gage,Ariana Nakta Samadpour,Ankunda Kariisa,Christopher N. Merrikh,Samuel I. Miller,David R. Sherman,David R. Sherman,Houra Merrikh +11 more
TL;DR: It is suggested that AMR development can be inhibited through inactivation of evolvability factors (potentially with “anti-evolution” drugs)—in particular, Mfd—providing an unexplored route toward battling the AMR crisis.
Journal ArticleDOI
An underlying mechanism for the increased mutagenesis of lagging-strand genes in Bacillus subtilis
Samuel Million-Weaver,Ariana Nakta Samadpour,Daniela A. Moreno-Habel,Patrick Nugent,Mitchell J. Brittnacher,Eli J. Weiss,Hillary S. Hayden,Samuel I. Miller,Ivan Liachko,Houra Merrikh +9 more
TL;DR: This work reports an underlying mechanism that increases mutation rates of lagging-strand genes in Bacillus subtilis and finds that this process is mediated through the transcription-dependent activity of the Y-family polymerase, PolY1, in transcription-coupled nucleotide excision repair.