Patrick Wong

TL;DR: To compare the clinical and laboratory features of IgG4‐related disease (IgG 4‐RD) and lymphocyte‐variant hypereosinophilic syndrome (L‐HES), two rare diseases that often present with lymphadenopathy, gastrointestinal symptoms, eOSinophilia, and elevated immunoglobulins/IgE are compared.

TL;DR: The results of these studies suggest a compensatory role for TDP1 in rhabdomyosarcoma after topoisomerase-I based therapy and further demonstrate that TDP 1 knockdown, PARP-1 inhibition, and dietary restriction have therapeutic validity.

TL;DR: The discovery that the expression of a protein tyrosine phosphatase, protein of regenerating liver-3 (PRL-3), is upregulated in colon cancer metastases provided an exciting indication that the altered regulation of specific protein tyosine phosphorylation events and signaling pathways might characterize these metastatic cells and/or be key in promoting the tumor-to-metastasis transition in this, and perhaps other, cancers of epithelial origin.

TL;DR: A novel case of IgG4‐RD with hypergammaglobulinemic hyperviscosity responsive to fludarabine and rituximab is described, which can be considered in patients with severe refractory disease.

TL;DR: A review of seven cases establishes IgG4‐RD as an important cause of polyclonal HVS and establishes it as an emerging disorder often associated with exuberant hypergammaglobulinemia.