P
Paul A. Morcos
Researcher at University of Oregon
Publications - 7
Citations - 1050
Paul A. Morcos is an academic researcher from University of Oregon. The author has contributed to research in topics: Zebrafish & Morpholino. The author has an hindex of 7, co-authored 7 publications receiving 1005 citations.
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Journal ArticleDOI
Inhibition of zebrafish fgf8 pre-mRNA splicing with morpholino oligos: A quantifiable method for gene knockdown
Journal ArticleDOI
A zebrafish sox9 gene required for cartilage morphogenesis
Yi-Lin Yan,Craig Miller,Robert M. Nissen,Amy Singer,Dong Liu,Anette Kirn,Bruce W. Draper,John Willoughby,Paul A. Morcos,Adam Amsterdam,Bon Chu Chung,Monte Westerfield,Pascal Haffter,Nancy Hopkins,Charles B. Kimmel,John H. Postlethwait +15 more
TL;DR: It is shown that jef (sox9a) is essential for both morphogenesis of condensations and overt cartilage differentiation and in morpholino-injected animals, the percent of splicing inhibition decreased from 80% at 28 hours post fertilization to 45% by 4 days.
Journal ArticleDOI
Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification.
Dong Liu,Hsin Chu,Lisa Maves,Yi-Lin Yan,Paul A. Morcos,John H. Postlethwait,Monte Westerfield +6 more
TL;DR: The results provide evidence for Fgf3- and FgF8-dependent and -independent genetic pathways for otic specification and support the notion that F gf3 and Ff8 function to induce both the otic placode and the epithelial organization of the oic vesicle.
Journal ArticleDOI
Achieving efficient delivery of morpholino oligos in cultured cells.
TL;DR: Optimization of delivery in HeLa cells is described and provides the basis for delivery in any cultured endocytic cell type.
Journal ArticleDOI
Turning gene function ON and OFF using sense and antisense photo-morpholinos in zebrafish.
Alexandra Tallafuss,Dan Gibson,Paul A. Morcos,Yongfu Li,Steve Seredick,Judith S. Eisen,Philip Washbourne +6 more
TL;DR: In this article, photo-cleavable MOs are used to activate or deactivate MO function by UV exposure in a temporal and spatial manner in a zebrafish embryo and in single cells.